miRNA General Information
miRNA Mature ID hsa-miR-196b-5p
miRNA Stemloop AC MI0001150
miRNA Stemloop ID hsa-mir-196b
Sequence uagguaguuuccuguuguuggg
TTD Target(s) Regulated by This miRNA Serine/threonine-protein kinase mTOR (mTOR) Successful Target Target Info [1]
PI3-kinase gamma (PIK3CG) Successful Target Target Info [1]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [2]
RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Target Info [1]
Apoptosis mediating surface antigen FAS (FAS) Clinical trial Target Target Info [3]
TGF-beta receptor type II (TGFBR2) Clinical trial Target Target Info [4]
Proto-oncogene c-Fos (c-Fos) Literature-reported Target Target Info [5]
Protein(s) Regulated by This miRNA Homeobox protein Hox-A10 Regulated Protein [6]
Homeobox protein Hox-A9 Regulated Protein [7]
Homeobox protein Hox-B7 Regulated Protein [8]
Homeobox protein Hox-B8 Regulated Protein [9]
Homeobox protein Hox-C8 Regulated Protein [10]
Homeobox protein Meis1 Regulated Protein [7]
Insulin-like growth factor 2 mRNA-binding protein 1 Regulated Protein [11]
Protein C-ets-2 Regulated Protein [12]
Radixin Regulated Protein [13]
T-cell surface glycoprotein CD8 alpha chain Regulated Protein [14]
Transcription factor GATA-6 Regulated Protein [15]
References
REF 1 miR-196b regulates gastric cancer cell proliferation and invasion via PI3K/AKT/mTOR signaling pathway. Oncol Lett. 2016 Mar;11(3):1745-1749.
REF 2 miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells. Hum Reprod. 2013 Mar;28(3):750-61.
REF 3 MicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells. Oncotarget. 2015 Feb 20;6(5):2843-55.
REF 4 MicroRNA-196a/b Mitigate Renal Fibrosis by Targeting TGF- Receptor 2. J Am Soc Nephrol. 2016 Oct;27(10):3006-3021.
REF 5 miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis. Cancer Res. 2016 Aug 15;76(16):4741-51.
REF 6 Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype.World J Gastroenterol. 2013 Nov 7;19(41):7078-88.
REF 7 miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun. 2012 Feb 21;3:688.
REF 8 MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer.PLoS One. 2013 Jul 4;8(7):e67846.
REF 9 Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi.PLoS One. 2008 May 21;3(5):e2248.
REF 10 Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis.Cancer Res. 2010 Oct 15;70(20):7894-904.
REF 11 miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1.Mol Cancer. 2015 Apr 8;14:79.
REF 12 Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells.Carcinogenesis. 2012 Apr;33(4):760-9.
REF 13 MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer.Cancer Lett. 2014 Sep 1;351(2):222-31.
REF 14 T cell post-transcriptional miRNA-mRNA interaction networks identify targets associated with susceptibility/resistance to collagen-induced arthritis. PLoS One. 2013;8(1):e54803.
REF 15 The miR-196b miRNA inhibits the GATA6 intestinal transcription factor and is upregulated in colon cancer patients.Oncotarget. 2017 Jan 17;8(3):4747-4759.

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