miRNA General Information
miRNA Mature ID hsa-miR-149-5p
miRNA Stemloop AC MI0000478
miRNA Stemloop ID hsa-mir-149
Sequence ucuggcuccgugucuucacuccc
TTD Target(s) Regulated by This miRNA Fibroblast growth factor receptor 1 (FGFR1) Successful Target Target Info [1]
Interleukin-6 (IL6) Successful Target Target Info [2]
Prostaglandin E2 receptor EP2 (PTGER2) Successful Target Target Info [2]
Fibroblast growth factor-21 (FGF21) Clinical trial Target Target Info [3]
Transcription factor Sp1 (SP1) Clinical trial Target Target Info [4]
Myeloid differentiation primary response protein MyD88 (MYD88) Literature-reported Target Target Info [5]
Apoptosis antigen ligand (CD178) Literature-reported Target Target Info [6]
Bcl-2-binding component 3 (BBC3) Literature-reported Target Target Info [7]
Forkhead box protein M1 (FOXM1) Literature-reported Target Target Info [8]
Protein(s) Regulated by This miRNA ARF GTPase-activating protein GIT1 Regulated Protein [9]
Glypican-1 Regulated Protein [1]
Protein phosphatase 1F Regulated Protein [11]
Zinc finger and BTB domain-containing protein 2 Regulated Protein [12]
References
REF 1 Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. J Cell Sci. 2014 Mar 15;127(Pt 6):1169-78.
REF 2 Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. Cell Res. 2015 May;25(5):588-603.
REF 3 MiR-577 inhibits pancreatic -cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetes. Genet Mol Res. 2015 Dec 1;14(4):15462-70.
REF 4 miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma. FEBS Lett. 2012 Sep 21;586(19):3309-16.
REF 5 MicroRNA-149 negatively regulates TLR-triggered inflammatory response in macrophages by targeting MyD88. J Cell Biochem. 2014 May;115(5):919-27.
REF 6 Inhibition of MicroRNA-149-5p Induces Apoptosis of Acute Myeloid Leukemia Cell Line THP-1 by Targeting Fas Ligand (FASLG). Med Sci Monit. 2016 Dec 25;22:5116-5123.
REF 7 A pre-microRNA-149 (miR-149) genetic variation affects miR-149 maturation and its ability to regulate the Puma protein in apoptosis. J Biol Chem. 2013 Sep 13;288(37):26865-77.
REF 8 miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1. Biochem Res Int. 2013;2013:506731.
REF 9 MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis.Oncogene. 2014 Sep 4;33(36):4496-507.
REF 10 Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. J Cell Sci. 2014 Mar 15;127(Pt 6):1169-78.
REF 11 miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F.Oncotarget. 2015 Nov 10;6(35):37808-23.
REF 12 MicroRNA-149 inhibits proliferation and cell cycle progression through the targeting of ZBTB2 in human gastric cancer.PLoS One. 2012;7(10):e41693.

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