Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0YK9D
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| Former ID |
DIB019123
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| Drug Name |
CHIR-99021
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| Synonyms |
CHIR99021; CHIR 99021; CT-99021; CT99021
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| Drug Type |
Small molecular drug
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| Indication | Allergic inflammation [ICD-11: 4A80-4A85] | Patented | [1] | |
| Graft rejection [ICD-11: NE84] | Patented | [1] | ||
| Structure |
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Download2D MOL |
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| Formula |
C22H18Cl2N8
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| Canonical SMILES |
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
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| InChI |
1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
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| InChIKey |
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
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| CAS Number |
CAS 252917-06-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14931758, 46052726, 77619611, 84982162, 90306847, 99222801, 99437061, 103566476, 103905640, 123105098, 124757128, 125163932, 125329941, 125333824, 126731259, 127443675, 131480740, 134216516, 135697745, 135727435, 136157396, 136367374, 136367993, 136920307, 137275880, 142261085, 144115822, 152043829, 152186750, 152258107, 152344405, 160646946, 162011409, 162037525, 162202606, 162211052, 162823708, 163685877, 163726080, 163780442, 163907957, 164042070, 164150165, 172087016, 172131585, 172649829, 174007034, 174528565, 180060723, 186006539
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| ChEBI ID |
CHEBI:91091
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. | |||
| REF 2 | Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. | |||
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