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Target General Information |
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Target ID |
T58970 |
Target Info
|
Target Name |
Extracellular signal-regulated kinase 2 (ERK2) |
Synonyms |
PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2 |
Target Type |
Clinical trial Target |
Gene Name |
MAPK1 |
Biochemical Class |
Kinase |
UniProt ID |
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Patent(s) and the Corresponding Patented Drug(s) |
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World Intellectual Property Organization (WIPO) |
Patent ID |
WO2015041534 |
Title |
P90Rsk In Combination with Raf/Erk/Mek. |
Abstract |
The current disclosure relates to pharmaceutical combinations and compositions useful in the treatment of certain types of cancer. The disclosure also relates to method of treatment these certain types of cancer. In particular, the disclosure relates to the combined use of an inhibitor of p90RSK and an inhibitor of another protein of the MAPK/ERK-pathway in the treatment of KRAS-, NRAS-or BRAF-mutated cancer, in particular in NRAS mutated melanoma. |
Applicant(s) |
Stichting Het Nederlands Kanker Instituut |
References |
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REF 1 |
Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78.
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