Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X2MQ
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| Former ID |
DIB018493
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| Drug Name |
17-phenyl-omega-trinor-PGE2
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| Synonyms |
17-phenyl-omega-trinor-prostaglandin E2; 17-phenyl-trinor-PGE2; 17-Ph-omega-trinor-PGE2; 17-phenyl-PGE2
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C23H30O5
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| Canonical SMILES |
C1C(C(C(C1=O)CC=CCCCC(=O)O)C=CC(CCC2=CC=CC=C2)O)O
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| InChI |
1S/C23H30O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-20,22,24,26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,22+/m0/s1
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| InChIKey |
FOBVMYJQWZOGGJ-XYRJXBATSA-N
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| CAS Number |
CAS 38315-43-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4266001, 7978573, 11038725, 15474352, 26754834, 26754835, 39316485, 47440000, 47736222, 50110796, 57358833, 74660904, 85787435, 92309785, 99300699, 99302217, 104046454, 113859000, 131342668, 135651383, 137146293, 142622838, 143020475, 179150412, 186016875, 229390806, 242475231, 250134045, 252377742, 252455509, 252457339, 252464504
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| ChEBI ID |
CHEBI:87820
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin E2 receptor EP1 (PTGER1) | Target Info | Agonist | [2] |
| Prostaglandin E2 receptor EP2 (PTGER2) | Target Info | Agonist | [2] | |
| Prostaglandin E2 receptor EP3 (PTGER3) | Target Info | Agonist | [3] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Pathways in cancer | ||||
| cAMP signaling pathway | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Renin secretion | ||||
| Regulation of lipolysis in adipocytes | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | PI3 kinase pathway | |||
| Reactome | Prostanoid ligand receptors | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Ovarian Infertility Genes | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1912). | |||
| REF 2 | Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. | |||
| REF 3 | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. | |||
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