Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U1XJ
|
|||
| Former ID |
DNC004362
|
|||
| Drug Name |
HBR-985
|
|||
| Synonyms |
Glicondamide; 52994-25-9; UNII-876SH4764F; C18H20ClN3O5S; 876SH4764F; 1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-methylurea; Glicondamide [INN]; 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-methylurea; AC1Q3LT7; CHEMBL12806; AC1L562G; SCHEMBL1818252; CTK4J6836; DTXSID10201026; ZINC537790; HB-985; AKOS030573774; ACM52994259; W0037; 5-chloro-2-methoxy-N-[2-[4-(methylcarbamoylsulfamoyl)phenyl]ethyl]benzamide
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C18H20ClN3O5S
|
|||
| Canonical SMILES |
CNC(=O)NS(=O)(=O)C1=CC=C(C=C1)CCNC(=O)C2=C(C=CC(=C2)Cl)OC
|
|||
| InChI |
1S/C18H20ClN3O5S/c1-20-18(24)22-28(25,26)14-6-3-12(4-7-14)9-10-21-17(23)15-11-13(19)5-8-16(15)27-2/h3-8,11H,9-10H2,1-2H3,(H,21,23)(H2,20,22,24)
|
|||
| InChIKey |
RXOBKRPNVDTZQF-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 52994-25-9
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ATP-binding cassette transporter C8 (ABCC8) | Target Info | Inhibitor | [1] |
| Inward rectifier potassium channel Kir6.2 (KCNJ11) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | ABC transporters | |||
| Insulin secretion | ||||
| Type II diabetes mellitus | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Pancreas Function | ||||
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | |||
| Reactome | ABC-family proteins mediated transport | |||
| Regulation of insulin secretion | ||||
| WikiPathways | Potassium Channels | |||
| Integration of energy metabolism | ||||
| Type II diabetes mellitus | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.