Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N1HE
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Former ID |
DIB021112
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Drug Name |
UCL1848
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Synonyms |
UCL-1848
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C28H34N4+2
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Canonical SMILES |
C1CCNC2=CC=[N+](CCCCC[N+]3=CC=C(C4=CC=CC=C43)NCC1)C5=CC=CC=C25
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InChI |
1S/C28H32N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22H,1-2,7-10,17-20H2/p+2
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InChIKey |
IOXVWOJJNCBJBX-UHFFFAOYSA-P
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CAS Number |
CAS 201147-53-7
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Calcium-activated potassium channel KCa2.1 (KCNN1) | Target Info | Blocker (channel blocker) | [2] |
Calcium-activated potassium channel KCa2.2 (KCNN2) | Target Info | Blocker (channel blocker) | [3] | |
Calcium-activated potassium channel KCa2.3 (KCNN3) | Target Info | Blocker (channel blocker) | [4] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2321). | |||
REF 2 | The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30. | |||
REF 3 | Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13;276(15):12249-56. | |||
REF 4 | SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34. |
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