Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I6MA
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| Former ID |
DIB019704
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| Drug Name |
DC-EBIO
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| Synonyms |
dichloro-EBIO
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C9H8Cl2N2O
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| Canonical SMILES |
CCN1C2=CC(=C(C=C2NC1=O)Cl)Cl
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| InChI |
1S/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14)
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| InChIKey |
LKHRMULASXZCLG-UHFFFAOYSA-N
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| CAS Number |
CAS 60563-36-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
854089, 6213728, 9268126, 11111113, 11114078, 14749342, 17404997, 24278396, 47349357, 50104848, 50104849, 53777540, 56463461, 57408420, 78240964, 85231020, 85789028, 90341651, 91703976, 92303913, 93578450, 113528213, 121361254, 123088606, 124749712, 124801469, 124879972, 124879973, 128501477, 135650163, 137248073, 162022940, 162247819, 163133887, 163563824, 163564388, 163724383, 163737669, 164212502, 178125684, 219402187, 223442446, 223519285, 226913755, 241110095, 241182418
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| ChEBI ID |
CHEBI:34662
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium-activated potassium channel KCa2.2 (KCNN2) | Target Info | Activator | [2] |
| Calcium-activated potassium channel KCa2.3 (KCNN3) | Target Info | Activator | [3] | |
| Calcium-activated potassium channel KCa3.1 (KCNN4) | Target Info | Activator | [4] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2324). | |||
| REF 2 | Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of ... J Biol Chem. 2005 Dec 16;280(50):41404-11. | |||
| REF 3 | Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57. | |||
| REF 4 | Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11. | |||
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