Drug Information
Drug General Information | Top | |||
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Drug ID |
D05GBH
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Former ID |
DIB005848
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Drug Name |
F4co vaccine
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Synonyms |
F4co vaccine (AIDS/HIV infection)
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Drug Type |
Vaccine
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Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Phase 2 | [1], [2] | |
Company |
GlaxoSmithKline plc
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Target and Pathway | Top | |||
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Target(s) | Human immunodeficiency virus Capsid p24 (HIV p24) | Target Info | . | [3] |
Human immunodeficiency virus Matrix p17 (HIV MA) | Target Info | . | [3] | |
Human immunodeficiency virus Negative factor (HIV nef) | Target Info | . | [3] | |
Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | . | [3] | |
Reactome | Uncoating of the HIV Virion | |||
Budding and maturation of HIV virion | ||||
Integration of provirus | ||||
Early Phase of HIV Life Cycle | ||||
Minus-strand DNA synthesis | ||||
Plus-strand DNA synthesis | ||||
2-LTR circle formation | ||||
Binding and entry of HIV virion | ||||
Membrane binding and targetting of GAG proteins | ||||
Assembly Of The HIV Virion | ||||
Integration of viral DNA into host genomic DNA | ||||
Autointegration results in viral DNA circles | ||||
APOBEC3G mediated resistance to HIV-1 infection | ||||
Vpr-mediated nuclear import of PICs | ||||
WikiPathways | Host Interactions of HIV factors | |||
HIV Life Cycle |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01218113) Efficacy and Safety of GSK Biologicals HIV Vaccine in Antiretroviral Therapy (ART)-naive HIV-1 Infected Persons. U.S. National Institutes of Health. | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027409) | |||
REF 3 | EP patent application no. 2621528, Vaccine. |
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