Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00YNI
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| Former ID |
DIB020150
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| Drug Name |
L-(cis)-diltiazem
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| Synonyms |
L-cis-diltiazem; CHEBI:82813; [(2R,3R)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate; L-(cis)-diltiazem; ent-diltiazem; cis-3-Acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one; (-)-cis-diltiazem; Lopac-D-2521; BSPBio_001357; SCHEMBL676914; GTPL2349; AC1L54N5; CHEMBL1397935; ZINC601259; HMS1791D19; HMS1989D19; NCGC00016818-04; NCGC00015332-01; NCGC00163133-03; NCGC00015332-02; NCGC00016818-01; CAS-33286-22-5; BRD-K81029756-001-02-8
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H26N2O4S
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| Canonical SMILES |
CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
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| InChI |
1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m0/s1
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| InChIKey |
HSUGRBWQSSZJOP-LEWJYISDSA-N
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| CAS Number |
CAS 56209-45-1
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:82813
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cyclic nucleotide-gated channel alpha-1 (CNGA1) | Target Info | Blocker (channel blocker) | [2] |
| Cyclic nucleotide-gated channel alpha-2 (CNGA2) | Target Info | Blocker (channel blocker) | [3] | |
| Cyclic nucleotide-gated channel alpha-3 (CNGA3) | Target Info | Inhibitor | [4] | |
| Cyclic nucleotide-gated channel beta-3 (CNGB3) | Target Info | Blocker (channel blocker) | [5] | |
| Voltage-gated calcium channel alpha Cav1.4 (CACNA1F) | Target Info | Inhibitor (gating inhibitor) | [6] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | |||
| Pathway Interaction Database | Visual signal transduction: Cones | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2349). | |||
| REF 2 | A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22;362(6422):764-7. | |||
| REF 3 | Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7. | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 396). | |||
| REF 5 | Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32. | |||
| REF 6 | Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):708-13. | |||
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