Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0A0YX
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| Former ID |
DNC008189
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| Drug Name |
SACCHARIN
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| Synonyms |
saccharin; 81-07-2; o-Sulfobenzimide; Saccharine; o-Benzoic sulfimide; Saccharimide; Benzosulfimide; o-Benzosulfimide; Benzoic sulfimide; Benzosulphimide; Saccharinose; Garantose; Saccharinol; Gluside; Saccharin acid; Benzosulfinide; Hermesetas; Saccharol; Sweeta; Saccharin insoluble; Glucid; Benzoic sulphimide; 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide; Saccharina; Zaharina; Sucrette; Sacarina; Kandiset; Sykose; Saxin; o-Benzoyl sulfimide; Benzo-2-sulphimide; Sucre edulcor; o-Benzoic sulphimide; Benzoylsulfonic Imide; o-Sulfobenzoic acid im
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C7H5NO3S
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=O)NS2(=O)=O
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| InChI |
1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
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| InChIKey |
CVHZOJJKTDOEJC-UHFFFAOYSA-N
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| CAS Number |
CAS 128-44-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14427, 71478, 607877, 839978, 3135133, 5012232, 5505082, 7848148, 8149757, 8153161, 10536361, 10589168, 11335339, 11360578, 11363107, 11365669, 11368231, 11372628, 11373977, 11376393, 11452613, 11452651, 11461550, 11485300, 11489248, 11491290, 11492264, 11494027, 14748396, 24846892, 24847625, 24854444, 25624371, 26612212, 26679430, 26737229, 26737259, 26748529, 26748530, 26753733, 29224206, 37412109, 47291006, 48034975, 48184866, 48414437, 48416900, 48424059, 49855916, 50107426
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| ChEBI ID |
CHEBI:32111
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacillales | ||||
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Studied Microbe: Jeotgalicoccus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Jeotgalicoccus was increased by Saccharin. | |||
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Studied Microbe: Sporosarcina
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Sporosarcina was increased by Saccharin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Bacteroides was increased by Saccharin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Adlercreutzia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Adlercreutzia was decreased by Saccharin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Turicibacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Turicibacter was increased by Saccharin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Anaerostipes was decreased by Saccharin. | |||
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Studied Microbe: Dorea
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Dorea was decreased by Saccharin. | |||
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Studied Microbe: Oscillospira
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Oscillospira was increased by Saccharin. | |||
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Studied Microbe: Roseburia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Roseburia was increased by Saccharin. | |||
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Studied Microbe: Ruminococcus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Ruminococcus was decreased by Saccharin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Mycobacteriales | ||||
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Studied Microbe: Corynebacterium
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Corynebacterium was increased by Saccharin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Akkermansia was decreased by Saccharin. | |||
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Studied Microbe: Akkermansia
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Liver inflammation | |||
| Description | The abundance of Akkermansia was increased by Saccharin. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5432). | |||
| REF 2 | Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol. 2017 Sep;107(Pt B):530-539. | |||
| REF 3 | Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct 9;514(7521):181-6. | |||
| REF 4 | Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. | |||
| REF 5 | Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. | |||
| REF 6 | Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of... Bioorg Med Chem Lett. 2008 Jan 15;18(2):836-41. | |||
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