Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T74312 Target Info
Target Name Fms-like tyrosine kinase 3 (FLT-3)
Synonyms
Stem cell tyrosine kinase 1; STK1; STK-1; Receptor-type tyrosine-protein kinase FLT3; Fetal liver kinase-2; FLT-3; FLK2; FLK-2; FL cytokine receptor; CD135
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Target Type Successful Target
Gene Name FLT3
Biochemical Class Kinase
UniProt ID
FLT3_HUMAN
Co-Targets of This Target  Top
Co-Target Name Human immunodeficiency virus Reverse transcriptase (HIV RT) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV RT
Synonyms
HIV p66 RT; HIV Exoribonuclease H
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Representative Drug(s) Zidovudine Drug Info IC50 = 0.0034 ug.mL-1 Click to Show More [1]
2 Zidovudine Drug Info EC50 = 2 nM [13]
Co-Target Name Fusion protein Bcr-Abl (Bcr-Abl) Successful Target
UniProt ID BCR_HUMAN-ABL1_HUMAN
Gene Name BCR-ABL1
Synonyms
BCR-ABL fusion protein; BCR-ABL
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Representative Drug(s) Ponatinib Drug Info EC50 = 0.05 nM [2]
Co-Target Name Proto-oncogene c-Ret (RET) Successful Target
UniProt ID RET_HUMAN
Gene Name RET
Synonyms
RET51; RET receptor tyrosine kinase; RET mutant Y791F; RET mutant V804M; RET mutant V804L; RET mutant S891A; RET mutant M918T; RET mutant G691S; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; Cadherin family member 12; CDHR16; CDHF12; C-ret
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Representative Drug(s) Ponatinib Drug Info IC50 = 0.3 nM Click to Show More [3]
2 TAK-659 Drug Info IC50 = 8.4 nM [12]
3 MK-2461 Drug Info IC50 = 640 nM [17]
Co-Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target
UniProt ID ABL1_HUMAN
Gene Name ABL1
Synonyms
p150; Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
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Representative Drug(s) Ponatinib Drug Info IC50 = 0.32 nM [4]
Co-Target Name Proto-oncogene c-Met (MET) Successful Target
UniProt ID MET_HUMAN
Gene Name MET
Synonyms
Tyrosine-protein kinase Met; Scatter factor receptor; SF receptor; Met proto-oncogene tyrosine kinase; Hepatocyte growth factor receptor; HGF/SF receptor; HGF-SF receptor; HGF receptor; C-met; C-Met receptor tyrosine kinase
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Representative Drug(s) MK-2461 Drug Info IC50 = 0.4 nM [5]
Co-Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target
UniProt ID FGFR1_HUMAN
Gene Name FGFR1
Synonyms
c-fgr; bFGF-R-1; bFGF-R; N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT2; FLT-2; FLG; FGFR-1; FGFBR; CEK; CD331 antigen; CD331; Basic fibroblast growth factor receptor 1; BFGFR
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Representative Drug(s) Ponatinib Drug Info IC50 = 0.7 nM Click to Show More [6]
2 MK-2461 Drug Info IC50 = 65 nM [17]
Co-Target Name Tyrosine-protein kinase UFO (AXL) Successful Target
UniProt ID UFO_HUMAN
Gene Name AXL
Synonyms
UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene
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Representative Drug(s) Gilteritinib Drug Info IC50 = 0.73 nM [7]
Co-Target Name Janus kinase 2 (JAK-2) Successful Target
UniProt ID JAK2_HUMAN
Gene Name JAK2
Synonyms
Tyrosine-protein kinase JAK2
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Representative Drug(s) Pacritinib Drug Info IC50 = 1 nM Click to Show More [8]
2 Pacritinib Drug Info IC50 = 19 nM [15]
3 MK-2461 Drug Info IC50 = 230 nM [17]
Co-Target Name Platelet-derived growth factor receptor beta (PDGFRB) Successful Target
UniProt ID PGFRB_HUMAN
Gene Name PDGFRB
Synonyms
Platelet-derived growth factor receptor 1; PDGFR1; PDGFR-beta; PDGFR-1; PDGFR; PDGF-R-beta; CD140b antigen; CD140b; CD140 antigen-like family member B; Beta-type platelet-derived growth factor receptor; Beta-PDGFR; Beta platelet-derived growth factor receptor
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Representative Drug(s) Ponatinib Drug Info IC50 = 1.2 nM Click to Show More [3]
2 Famitinib Drug Info IC50 = 4 nM [11]
Co-Target Name Fibroblast growth factor receptor 2 (FGFR2) Successful Target
UniProt ID FGFR2_HUMAN
Gene Name FGFR2
Synonyms
Keratinocyte growth factor receptor 2; Keratinocyte growth factor receptor; KSAM; KGFR; K-sam; FGFR-2; FGF-2 receptor; CD332; BEK
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Representative Drug(s) Ponatinib Drug Info IC50 = 1.3 nM Click to Show More [3]
2 MK-2461 Drug Info IC50 = 39 nM [17]
Co-Target Name Vascular endothelial growth factor receptor 2 (KDR) Successful Target
UniProt ID VGFR2_HUMAN
Gene Name KDR
Synonyms
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
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Representative Drug(s) Ponatinib Drug Info IC50 = 1.5 nM Click to Show More [9]
2 Famitinib Drug Info IC50 = 2 nM [11]
3 MK-2461 Drug Info IC50 = 44 nM [17]
4 TAK-659 Drug Info IC50 = 88 nM [12]
5 Midostaurin Drug Info IC50 = 250 nM [20]
6 Quizartinib Drug Info IC50 = 430 nM [21]
Co-Target Name Tyrosine-protein kinase Kit (KIT) Successful Target
UniProt ID KIT_HUMAN
Gene Name KIT
Synonyms
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; p145 c-kit; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; Mast/stem cell growth factor receptor Kit; CD117 antigen; CD117; C-kit
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Representative Drug(s) Ponatinib Drug Info IC50 = 1.7 nM Click to Show More [10]
2 Famitinib Drug Info IC50 = 2 nM [11]
3 Pexidartinib Drug Info IC50 = 27 nM [16]
4 Midostaurin Drug Info IC50 = 109 nM [19]
Co-Target Name Tyrosine-protein kinase SYK (SYK) Successful Target
UniProt ID KSYK_HUMAN
Gene Name SYK
Synonyms
p72-Syk; Spleen tyrosine kinase
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Representative Drug(s) TAK-659 Drug Info IC50 = 2 nM [12]
Co-Target Name Proto-oncogene c-Src (SRC) Successful Target
UniProt ID SRC_HUMAN
Gene Name SRC
Synonyms
pp60c-src; Tyrosine kinase (pp60(src)); Src tyrosine kinase; SRC1; Proto-oncogene tyrosine-protein kinase Src; Pp60(src); P60-Src; C-src TK; C-Src
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Representative Drug(s) Ponatinib Drug Info IC50 = 2.5 nM [3]
Co-Target Name Platelet-derived growth factor receptor alpha (PDGFRA) Successful Target
UniProt ID PGFRA_HUMAN
Gene Name PDGFRA
Synonyms
RHEPDGFRA; Platelet-derived growth factor receptor 2; Platelet-derived growth factor alpha receptor; PDGFR2; PDGFR-alpha; PDGFR-2; PDGF-R-alpha; CD140a antigen; CD140a; CD140 antigen-like family member A; Alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor
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Representative Drug(s) Ponatinib Drug Info IC50 = 2.6 nM Click to Show More [3]
2 Quizartinib Drug Info IC50 = 42 nM [18]
3 TAK-659 Drug Info IC50 = 45 nM [12]
4 MK-2461 Drug Info IC50 < 100 nM [17]
Co-Target Name Human immunodeficiency virus Protease (HIV PR) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV PR
Synonyms
HIV Retropepsin; HIV PR
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Representative Drug(s) Zidovudine Drug Info IC50 = 6 nM [14]
Co-Target Name Tropomyosin-related kinase A (TrkA) Successful Target
UniProt ID NTRK1_HUMAN
Gene Name NTRK1
Synonyms
gp140trk; Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; Neurotrophic tyrosine kinase receptor type 1; NGF-trk receptor type A; MTC; High affinity nerve growth factor receptor
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Representative Drug(s) MK-2461 Drug Info IC50 = 46 nM [17]
Co-Target Name BDNF/NT-3 growth factors receptor (TrkB) Successful Target
UniProt ID NTRK2_HUMAN
Gene Name NTRK2
Synonyms
Tropomyosin-related kinase B; TrkB tyrosine kinase; Trk-B; TRKB; Neurotrophic tyrosine kinase receptor type 2; GP145-TrkB
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Representative Drug(s) MK-2461 Drug Info IC50 = 61 nM [17]
Co-Target Name Janus kinase 3 (JAK-3) Successful Target
UniProt ID JAK3_HUMAN
Gene Name JAK3
Synonyms
Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK
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Representative Drug(s) TAK-659 Drug Info IC50 = 114 nM Click to Show More [12]
2 Pacritinib Drug Info IC50 = 520 nM [15]
Co-Target Name Epidermal growth factor receptor (EGFR) Successful Target
UniProt ID EGFR_HUMAN
Gene Name EGFR
Synonyms
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
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Representative Drug(s) Ponatinib Drug Info IC50 ~ 1000 nM [3]
Co-Target Name Tyrosine-protein kinase Lyn (JTK8) Clinical trial Target
UniProt ID LYN_HUMAN
Gene Name LYN
Synonyms
p56Lyn; p53Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Lck/Yes-related novel protein tyrosine kinase
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Representative Drug(s) Ponatinib Drug Info IC50 = 0.24 nM [9]
Co-Target Name Macrophage-stimulating protein receptor (RON) Clinical trial Target
UniProt ID RON_HUMAN
Gene Name MST1R
Synonyms
p185Ron; Proteintyrosine kinase 8; Macrophagestimulating protein receptor beta chain; Macrophagestimulating protein receptor; MST1R; MSP receptor; CDw136; CD136
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Representative Drug(s) MK-2461 Drug Info IC50 = 7 nM [17]
Co-Target Name Fibroblast growth factor receptor 4 (FGFR4) Clinical trial Target
UniProt ID FGFR4_HUMAN
Gene Name FGFR4
Synonyms
TKF; JTK2; FGFR-4; CD334
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Representative Drug(s) Ponatinib Drug Info IC50 = 7.1 nM [3]
Co-Target Name Fibroblast growth factor receptor 3 (FGFR3) Clinical trial Target
UniProt ID FGFR3_HUMAN
Gene Name FGFR3
Synonyms
JTK4; FGFR-3; CD333
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Representative Drug(s) Ponatinib Drug Info IC50 = 9.4 nM Click to Show More [3]
2 MK-2461 Drug Info IC50 = 50 nM [17]
Co-Target Name Vascular endothelial growth factor receptor 1 (FLT-1) Clinical trial Target
UniProt ID VGFR1_HUMAN
Gene Name FLT1
Synonyms
Vascular permeability factor receptor; VEGFR1; VEGFR-1; VEGF-1 receptor; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1; FRT; FLT
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Representative Drug(s) MK-2461 Drug Info IC50 = 10 nM Click to Show More [17]
2 Ponatinib Drug Info IC50 = 20.9 nM [3]
Co-Target Name Macrophage colony-stimulating factor 1 receptor (CSF1R) Clinical trial Target
UniProt ID CSF1R_HUMAN
Gene Name CSF1R
Synonyms
Proto-oncogene c-Fms; M-CSF-R; FMS; CSF-1R; CSF-1-R; CSF-1 receptor; CD115
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Representative Drug(s) Pexidartinib Drug Info IC50 = 10.8 nM Click to Show More [22]
2 Lestaurtinib Drug Info IC50 = 31 nM [24]
3 Midostaurin Drug Info IC50 = 142 nM [24]
Co-Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target
UniProt ID RIPK1_HUMAN
Gene Name RIPK1
Synonyms
Receptor-interacting serine/threonine-protein kinase 1; RIP1; RIP-1; RIP; Cell death protein RIP
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Representative Drug(s) Ponatinib Drug Info IC50 = 12 nM [23]
Co-Target Name Tyrosine-protein kinase Mer (MERTK) Clinical trial Target
UniProt ID MERTK_HUMAN
Gene Name MERTK
Synonyms
Receptor tyrosine kinase MerTK; Proto-oncogene c-Mer
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Representative Drug(s) MK-2461 Drug Info IC50 = 24 nM [17]
Co-Target Name Checkpoint kinase-1 (CHK1) Clinical trial Target
UniProt ID CHK1_HUMAN
Gene Name CHEK1
Synonyms
Serine/threonine-protein kinase Chk1; Chk1; Cell cycle checkpoint kinase; CHK1 checkpoint homolog
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Representative Drug(s) TAK-659 Drug Info IC50 = 50 nM [12]
Co-Target Name TYK2 tyrosine kinase (TYK2) Successful Target
UniProt ID TYK2_HUMAN
Gene Name TYK2
Synonyms
Non-receptor tyrosine-protein kinase TYK2
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Representative Drug(s) Pacritinib Drug Info IC50 = 50 nM [15]
Co-Target Name PAK-4 protein kinase (PAK4) Clinical trial Target
UniProt ID PAK4_HUMAN
Gene Name PAK4
Synonyms
p21-activated kinase 4; Serine/threonine-protein kinase PAK 4; PAK-4; KIAA1142
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Representative Drug(s) TAK-659 Drug Info IC50 = 76 nM [12]
Co-Target Name Vascular endothelial growth factor receptor 3 (FLT-4) Clinical trial Target
UniProt ID VGFR3_HUMAN
Gene Name FLT4
Synonyms
VEGFR3; VEGFR-3; VEGF-3 receptor; Tyrosine-protein kinase receptor FLT4; Fms-like tyrosine kinase 4
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Representative Drug(s) MK-2461 Drug Info IC50 = 78 nM [17]
Co-Target Name Aurora kinase A (AURKA) Clinical trial Target
UniProt ID AURKA_HUMAN
Gene Name AURKA
Synonyms
hARK1; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; STK6; STK15; IAK1; Breast tumor-amplified kinase; BTAK; Aurora/IPL1-related kinase 1; Aurora-related kinase 1; Aurora-A; Aurora 2; AYK1; AURA; ARK1; ARK-1; AIRK1; AIK
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Representative Drug(s) Midostaurin Drug Info IC50 = 80 nM Click to Show More [20]
2 MK-2461 Drug Info IC50 = 290 nM [17]
Co-Target Name Tyrosine-protein kinase ZAP-70 (ZAP-70) Patented-recorded Target
UniProt ID ZAP70_HUMAN
Gene Name ZAP70
Synonyms
Syk-related tyrosine kinase; SRK; 70 kDa zeta-chain associated protein
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Representative Drug(s) TAK-659 Drug Info IC50 = 75 nM [12]
Co-Target Name Ephrin type-A receptor 1 (EPHA1) Literature-reported Target
UniProt ID EPHA1_HUMAN
Gene Name EPHA1
Synonyms
hEpha1; Tyrosine-protein kinase receptor EPH; Erythropoietin-producing hepatoma receptor; EPHT1; EPHT; EPH tyrosine kinase 1; EPH tyrosine kinase; EPH
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Representative Drug(s) TAK-659 Drug Info IC50 = 31 nM [12]
Co-Target Name Proto-oncogene c-Fer (FER) Literature-reported Target
UniProt ID FER_HUMAN
Gene Name FER
Synonyms
p94-Fer; Tyrosine-protein kinase Fer; Tyrosine kinase 3; TYK3; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Feline encephalitis virus-related kinase FER
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Representative Drug(s) TAK-659 Drug Info IC50 = 51 nM [12]
Co-Target Name Phosphorylase kinase testis gamma 2 (PHKG2) Literature-reported Target
UniProt ID PHKG2_HUMAN
Gene Name PHKG2
Synonyms
Phosphorylase kinase subunit gamma-2; Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; PSK-C3; PHK-gamma-T; PHK-gamma-LT
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Representative Drug(s) TAK-659 Drug Info IC50 = 226 nM [12]
Co-Target Name Serine/threonine-protein kinase RIPK2 (RIPK2) Co-Target
UniProt ID RIPK2_HUMAN
Gene Name RIPK2
Synonyms
Receptor-interacting serine/threonine-protein kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2
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Representative Drug(s) Ponatinib Drug Info IC50 = 1 nM [23]
Co-Target Name Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) Co-Target
UniProt ID RIPK3_HUMAN
Gene Name RIPK3
Synonyms
RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3
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Representative Drug(s) Ponatinib Drug Info IC50 = 1.6 nM [23]
Co-Target Name Tyrosine-protein kinase ABL1 (ABL1) Co-Target
UniProt ID ABL1_HUMAN
Gene Name ABL1
Synonyms
Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
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Representative Drug(s) Ponatinib Drug Info IC50 = 40 nM [25]
Co-Target Name Tyrosine-protein kinase ABL2 (ABL2) Co-Target
UniProt ID ABL2_HUMAN
Gene Name ABL2
Synonyms
Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
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Representative Drug(s) Ponatinib Drug Info IC50 = 40 nM [25]
Co-Target Name Coiled coil domain containing protein 6-Proto oncogene c Ret complex (CCDC6-RET) Co-Target
UniProt ID CCDC6_HUMAN-RET_HUMAN
Gene Name CCDC6-RET
Representative Drug(s) Ponatinib Drug Info IC50 = 180.4 nM [26]
References  Top
REF 1 Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review. Eur J Med Chem. 2019 Nov 1;181:111566.
REF 2 Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors. J Med Chem. 2016 Apr 28;59(8):3886-905.
REF 3 Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors. Eur J Med Chem. 2017 Jan 27;126:122-32.
REF 4 Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. J Med Chem. 2013 Feb 14;56(3):879-94.
REF 5 Recent advances in the development of dual VEGFR and c-Met small molecule inhibitors as anticancer drugs. Eur J Med Chem. 2016 Jan 27;108:495-504.
REF 6 Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3beta (GSK-3beta) with cellular activity of promoting glucose uptake. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5639-43.
REF 7 Dual FLT3 inhibitors: Against the drug resistance of acute myeloid leukemia in recent decade. Eur J Med Chem. 2019 Sep 15;178:468-483.
REF 8 Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines. J Med Chem. 2016 Sep 22;59(18):8233-62.
REF 9 An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors. Eur J Med Chem. 2017 Jan 27;126:476-90.
REF 10 Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT. J Med Chem. 2017 Nov 9;60(21):8801-15.
REF 11 Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of 2-indolinone derivatives. J Med Chem. 2010 Nov 25;53(22):8140-9.
REF 12 Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorg Med Chem Lett. 2016 Dec 15;26(24):5947-50.
REF 13 Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase. J Med Chem. 2000 May 18;43(10):1927-39.
REF 14 Thiadiazole derivatives: highly potent and specific HIV-1 reverse transcriptase inhibitors. J Med Chem. 1995 Jun 9;38(12):2038-40.
REF 15 Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma. J Med Chem. 2011 Jul 14;54(13):4638-58.
REF 16 Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases. Eur J Med Chem. 2019 Dec 15;184:111710.
REF 17 Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. J Med Chem. 2011 Jun 23;54(12):4092-108.
REF 18 Activity of 2,6,9-trisubstituted purines as potent PDGFRalpha kinase inhibitors with antileukaemic activity. Eur J Med Chem. 2019 Nov 15;182:111663.
REF 19 Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia. J Med Chem. 2019 Dec 26;62(24):11135-11150.
REF 20 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations. Eur J Med Chem. 2015 Jul 15;100:151-61.
REF 21 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorg Med Chem Lett. 2012 Jul 15;22(14):4654-9.
REF 22 Design, Synthesis, and Structure-Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5- d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors. J Med Chem. 2018 Mar 22;61(6):2353-71.
REF 23 Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives. J Med Chem. 2020 Feb 27;63(4):1490-1510.
REF 24 Colony stimulating factor-1 receptor as a target for small molecule inhibitors. Bioorg Med Chem. 2010 Mar 1;18(5):1789-97.
REF 25 Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8.
REF 26 Discovery of 4-chloro-3-(5-(pyridin-3-yl)-1,2,4-oxadiazole-3-yl)benzamides as novel RET kinase inhibitors. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5679-5684.

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