Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T32578 Target Info
Target Name Interleukin-6 (IL6)
Synonyms
Interferon beta-2; IL-6; IFNB2; IFN-beta-2; Hybridoma growth factor; CTL differentiation factor; CDF; BSF-2; B-cell stimulatory factor 2
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Target Type Successful Target
Gene Name IL6
Biochemical Class Cytokine: interleukin
UniProt ID
IL6_HUMAN
Co-Targets of This Target  Top
Co-Target Name Phosphodiesterase 4A (PDE4A) Successful Target
UniProt ID PDE4A_HUMAN
Gene Name PDE4A
Synonyms
cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Type 4A cAMP phosphodiesterase; PDE46; DPDE2
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Representative Drug(s) Ibudilast Drug Info IC50 = 54 nM [1]
Co-Target Name Phosphodiesterase 4D (PDE4D) Successful Target
UniProt ID PDE4D_HUMAN
Gene Name PDE4D
Synonyms
cAMP-specific 3',5'-cyclic phosphodiesterase 4D; PDE43; DPDE3
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Representative Drug(s) Ibudilast Drug Info IC50 = 166 nM [1]
Co-Target Name Phosphodiesterase 4B (PDE4B) Clinical trial Target
UniProt ID PDE4B_HUMAN
Gene Name PDE4B
Synonyms
cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Type 4B cAMP phosphodiesterase; Type 4 cyclic adenosine monophosphate phosphodiesterase (type 4 PDE); PDE32; DPDE4
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Representative Drug(s) Ibudilast Drug Info IC50 = 65 nM [1]
Co-Target Name Phosphodiesterase 4C (PDE4C) Patented-recorded Target
UniProt ID PDE4C_HUMAN
Gene Name PDE4C
Synonyms
cAMP-specific 3',5'-cyclic phosphodiesterase 4C; PDE21; DPDE1
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Representative Drug(s) Ibudilast Drug Info IC50 = 239 nM [1]
References  Top
REF 1 Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. J Med Chem. 2008 Sep 25;51(18):5471-89.

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