Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23761 | Target Info | |||
| Target Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) | ||||
| Synonyms |
SERCA pump; SERCA; Calcium-transporting ATPase; Calcium pump; Ca2+-ATPase; Ca(2+)-ATPase; ATP4
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Acid anhydrides hydrolase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Albendazole monooxygenase (CYP3A4) | Clinical trial Target | ||||
| UniProt ID | CP3A4_HUMAN | |||||
| Gene Name | CYP3A4 | |||||
| Synonyms |
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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| Representative Drug(s) | Piperaquine | Drug Info | Ki = 90 nM | [1] | ||
| Co-Target Name | GABA-A receptor anion channel | Co-Target | ||||
| UniProt ID | GBRE_HUMAN; GBRP_HUMAN | |||||
| Gene Name | GABRE; GABRP | |||||
| Representative Drug(s) | Artemisinin SP | Drug Info | Ki = 54.95 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The Development Process for Discovery and Clinical Advancement of Modern Antimalarials. J Med Chem. 2019 Dec 12;62(23):10526-10562. | ||||
| REF 2 | Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists. Eur J Med Chem. 2014 Sep 12;84:404-16. | ||||
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