Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P0SZ
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| Former ID |
DAP001504
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| Drug Name |
Piperaquine
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| Synonyms |
Piperaquinoline; Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-); Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-(9CI); 1,3-bis(1-(7-chloro-4'-quinolyl)-4'-piperazinyl)propane; 1,3-bis(4-(7'-chloro-4'-quinoline)-1-piperazine); 4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline); 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C29H32Cl2N6
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| Canonical SMILES |
C1CN(CCN1CCCN2CCN(CC2)C3=C4C=CC(=CC4=NC=C3)Cl)C5=C6C=CC(=CC6=NC=C5)Cl
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| InChI |
1S/C29H32Cl2N6/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29/h2-9,20-21H,1,10-19H2
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| InChIKey |
UCRHFBCYFMIWHC-UHFFFAOYSA-N
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| CAS Number |
CAS 4085-31-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5950601, 10240000, 15334392, 29302678, 50043136, 57340047, 80274398, 92251569, 103134334, 103261382, 104415414, 117470297, 118048658, 118844030, 125350088, 129349514, 131314023, 135077962, 137123599, 138218944, 139440458, 143493527, 152035592, 152241247, 163653072, 164232665, 164824367, 174006179, 196105912, 198972196, 223701321, 224062913, 226500372, 249614087, 251912304, 251916614, 252411866
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| ChEBI ID |
CHEBI:91231
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. | |||
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