Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T17448 Target Info
Target Name Histamine N-methyltransferase (HNMT)
Synonyms
Histamine-N-methyltransferase; HNMT; HMT
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Target Type Successful Target
Gene Name HNMT
Biochemical Class Methyltransferase
UniProt ID
HNMT_HUMAN
Co-Targets of This Target  Top
Co-Target Name Histamine H1 receptor (H1R) Successful Target
UniProt ID HRH1_HUMAN
Gene Name HRH1
Synonyms
HH1R; H1R
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Representative Drug(s) Diphenhydramine Drug Info Ki = 14.79 nM [1]
Co-Target Name Debrisoquine 4-hydroxylase (CYP2D6) Successful Target
UniProt ID CP2D6_HUMAN
Gene Name CYP2D6
Synonyms
P450-DB1; Cytochrome P450-DB1; Cytochrome P450 2D6; CYPIID6; CYP2DL1
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Representative Drug(s) Amodiaquine Drug Info IC50 = 640 nM [2]
Co-Target Name Cytochrome P450 2J2 (CYP2J2) Co-Target
UniProt ID CP2J2_HUMAN
Gene Name CYP2J2
Synonyms
Albendazole monooxygenase (hydroxylating); Albendazole monooxygenase (sulfoxide-forming); Arachidonic acid epoxygenase; Hydroperoxy icosatetraenoate isomerase; CYPIIJ2
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Representative Drug(s) Amodiaquine Drug Info IC50 = 990 nM [2]
References  Top
REF 1 Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6274-80.
REF 2 Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug Metab Dispos. 2013 Jan;41(1):60-71.

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