Co-Target(s) Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T11288 | Target Info | |||
Target Name | Multidrug resistance-associated protein 1 (ABCC1) | ||||
Synonyms |
MRP1; MRP; Leukotriene C(4) transporter; LTC4 transporter; ATP-binding cassette sub-family C member 1
Click to Show/Hide
|
||||
Target Type | Successful Target | ||||
Gene Name | ABCC1 | ||||
Biochemical Class | ABC transporter | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
---|---|---|---|---|---|---|
Co-Target Name | S-mephenytoin 4-hydroxylase (CYP2C9) | Successful Target | ||||
UniProt ID | CP2C9_HUMAN | |||||
Gene Name | CYP2C9 | |||||
Synonyms |
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
Click to Show/Hide
|
|||||
Representative Drug(s) | Benzbromarone | Drug Info | Ki = 19 nM | [1] | ||
Co-Target Name | Urate anion exchanger 1 (URAT1) | Successful Target | ||||
UniProt ID | S22AC_HUMAN | |||||
Gene Name | SLC22A12 | |||||
Synonyms |
UNQ6453/PRO34004; Solute carrier family 22 member 12; Renal-specific transporter; RST; Organic anion transporter 4-like protein; OATL4
Click to Show/Hide
|
|||||
Representative Drug(s) | Benzbromarone | Drug Info | IC50 = 22 nM | [2] | ||
Co-Target Name | Aldo-keto reductase family 1 member C1 (AK1C1_HUMAN) | Co-Target | ||||
UniProt ID | AK1C1_HUMAN | |||||
Gene Name | AKR1C1 | |||||
Synonyms |
20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD1; Chlordecone reductase homolog HAKRC; High-affinity hepatic bile acid-binding protein; HBAB
Click to Show/Hide
|
|||||
Representative Drug(s) | Benzbromarone | Drug Info | IC50 = 48 nM | [3] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | Charge and substituent effects on affinity and metabolism of benzbromarone-based CYP2C19 inhibitors. J Med Chem. 2004 Dec 30;47(27):6768-76. | ||||
REF 2 | The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. Medchemcomm. 2016;7:1587-95. | ||||
REF 3 | Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20... J Med Chem. 2009 May 28;52(10):3259-64. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.