| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T49368 | ||||
| Target Name | mRNA of PKC-delta | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | LY-326449 | Drug Info | IC50 = 690 nM | [534154] | |
| Dihexan-3-yl 5-(hydroxymethyl)isophthalate | Drug Info | Ki = 915 nM | [530134] | ||
| GF-109203 | Drug Info | IC50 = 32 nM | [529049] | ||
| PROSTRATIN | Drug Info | Ki = 190 nM | [527606] | ||
| BALANOL | Drug Info | IC50 = 30 nM | |||
| Bryostatin-1 | Drug Info | Ki = 0.44 nM | [530134] | ||
| Diheptan-3-yl 5-(hydroxymethyl)isophthalate | Drug Info | Ki = 529 nM | [530134] | ||
| Dicarba-Closo-Dodecaborane analogue | Drug Info | Ki = 1.8 nM | [525598] | ||
| 8-Octyl-benzolactam-V9 | Drug Info | Ki = 216 nM | [528158] | ||
| References | |||||
| Ref 534154 | J Med Chem. 1996 Jul 5;39(14):2664-71.(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. | ||||
| Ref 530134 | J Med Chem. 2009 Jul 9;52(13):3969-81.Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. | ||||
| Ref 529049 | J Biol Chem. 2007 Nov 9;282(45):33052-63. Epub 2007 Sep 17.Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. | ||||
| Ref 527606 | J Med Chem. 1992 May 29;35(11):1978-86.A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. | ||||
| Ref 530134 | J Med Chem. 2009 Jul 9;52(13):3969-81.Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. | ||||
| Ref 530134 | J Med Chem. 2009 Jul 9;52(13):3969-81.Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. | ||||
| Ref 525598 | Bioorg Med Chem Lett. 1999 Sep 6;9(17):2561-4.Protein kinase C modulators bearing dicarba-CLOSO-dodecaborane as a hydrophobic pharmacophore. | ||||
| Ref 528158 | J Med Chem. 2006 May 4;49(9):2681-8.Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. | ||||
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