Drug Information

Drug General Information
Drug ID
D04AXH
Former ID
DNC006485
Drug Name
8-Octyl-benzolactam-V9
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528158]
Structure
Download
2D MOL

3D MOL
Formula
C24H40N2O2
Canonical SMILES
CCCCCCCCC1=C2CCC(NC(=O)C(N(C2=CC=C1)C)C(C)C)CO
InChI
1S/C24H40N2O2/c1-5-6-7-8-9-10-12-19-13-11-14-22-21(19)16-15-20(17-27)25-24(28)23(18(2)3)26(22)4/h11,13-14,18,20,23,27H,5-10,12,15-17H2,1-4H3,(H,25,28)/t20-,23-/m0/s1
InChIKey
IDVIOLNZWSXZGL-REWPJTCUSA-N
PubChem Compound ID
11574614
Target and Pathway
Target(s) mRNA of human PKC-eta Target Info Inhibitor [528158]
mRNA of Protein kinase C-theta Target Info Inhibitor [528158]
Protein kinase C gamma type Target Info Inhibitor [528158]
mRNA of PKC-delta Target Info Inhibitor [528158]
mRNA of PKC-epsilon Target Info Inhibitor [528158]
KEGG Pathway Vascular smooth muscle contraction
Tight junction
Inflammatory mediator regulation of TRP channelshsa04064:NF-kappa B signaling pathway
T cell receptor signaling pathway
Inflammatory mediator regulation of TRP channels
Adipocytokine signaling pathway
Measleshsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
mTOR signaling pathway
Wnt signaling pathway
VEGF signaling pathway
Focal adhesion
Gap junction
Natural killer cell mediated cytotoxicity
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Insulin secretion
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04062:Chemokine signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Type II diabetes mellitushsa04022:cGMP-PKG signaling pathway
Type II diabetes mellitus
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
T cell activation
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
B cell activation
Inflammation mediated by chemokine and cytokine signaling pathway
CCKR signaling map ST
Pathway Interaction Database Endothelins
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytesendothelinpathway:Endothelins
TCR signaling in na&#xef
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
TCR signaling in na&#xef
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Downstream signaling in na&#xef
Endothelins
Retinoic acid receptors-mediated signaling
IL8- and CXCR2-mediated signaling events
PAR1-mediated thrombin signaling events
IL8- and CXCR1-mediated signaling eventsendothelinpathway:Endothelins
LPA receptor mediated events
IGF1 pathway
Ceramide signaling pathway
IFN-gamma pathway
ErbB1 downstream signaling
Syndecan-4-mediated signaling events
IL6-mediated signaling events
PDGFR-beta signaling pathway
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-2-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Alpha-synuclein signalingendothelinpathway:Endothelins
LPA4-mediated signaling events
CDC42 signaling events
IL2-mediated signaling events
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Reactome Effects of PIP2 hydrolysis
G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
G alpha (z) signalling eventsR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+R-HSA-111465:Apoptotic cleavage of cellular proteins
Calmodulin induced events
DAG and IP3 signaling
Role of phospholipids in phagocytosis
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Interferon gamma signalingR-HSA-114508:Effects of PIP2 hydrolysis
WikiPathways Calcium Regulation in the Cardiac Cell
Insulin Signaling
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
MAPK Signaling Pathway
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Oncostatin M Signaling Pathway
Signaling Pathways in Glioblastoma
miRs in Muscle Cell Differentiation
GPCR downstream signaling
Effects of PIP2 hydrolysisWP69:TCR Signaling Pathway
Fc epsilon receptor (FCERI) signaling
Corticotropin-releasing hormone
TCR signaling
Netrin-1 signaling
Effects of PIP2 hydrolysis
Apoptotic execution phaseWP536:Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway Netpath
DAG and IP3 signaling
Opioid Signalling
Response to elevated platelet cytosolic Ca2+WP69:TCR Signaling Pathway
Type II interferon signaling (IFNG)
EGF/EGFR Signaling Pathway
IL-6 signaling pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
AGE/RAGE pathway
B Cell Receptor Signaling Pathway
Apoptotic execution phase
Type II diabetes mellitusWP666:Hypothetical Network for Drug Addiction
Physiological and Pathological Hypertrophy of the Heart
References
Ref 528158J Med Chem. 2006 May 4;49(9):2681-8.Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.
Ref 528158J Med Chem. 2006 May 4;49(9):2681-8.Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.

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