| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T30823 | ||||
| Target Name | M-phase inducer phosphatase 1 | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | 1-dodecyl-1H-indole-2,3-dione | Drug Info | IC50 = 15000 nM | [529444] | |
| 4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione | Drug Info | IC50 = 7060 nM | [527986] | ||
| (E)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid | Drug Info | IC50 = 13000 nM | [529444] | ||
| 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione | Drug Info | IC50 = 10880 nM | [527986] | ||
| 2-(1-dodecyl-1H-indol-3-yl)acetic acid | Drug Info | IC50 = 8000 nM | [529444] | ||
| NSC-95397 | Drug Info | IC50 = 5500 nM | [530189] | ||
| (Z)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid | Drug Info | IC50 = 12000 nM | [529444] | ||
| 3-isopropyl-4-phenylnaphthalene-1,2-dione | Drug Info | IC50 = 7830 nM | [527986] | ||
| 3-isopropyl-4-(phenylthio)naphthalene-1,2-dione | Drug Info | IC50 = 5860 nM | [527986] | ||
| 3-isopropylnaphthalene-1,2-dione | Drug Info | IC50 = 11180 nM | [527986] | ||
| References | |||||
| Ref 529444 | Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. Epub 2008 Apr 15.Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
| Ref 529444 | Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. Epub 2008 Apr 15.Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
| Ref 529444 | Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. Epub 2008 Apr 15.Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. | ||||
| Ref 530189 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4330-4. Epub 2009 May 27.Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. | ||||
| Ref 529444 | Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. Epub 2008 Apr 15.Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
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