| Drug General Information |
| Drug ID |
D0J1KH
|
| Former ID |
DNC007961
|
| Drug Name |
NSC-95397
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H14O4S2
|
| Canonical SMILES |
C1=CC=C2C(=C1)C(=O)C(=C(C2=O)SCCO)SCCO
|
| InChI |
1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
|
| InChIKey |
MAASHDQFQDDECQ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
M-phase inducer phosphatase 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| M-phase inducer phosphatase 1 |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
MAPK signaling pathway
|
|
Cell cycle
|
|
Progesterone-mediated oocyte maturation
|
|
MicroRNAs in cancerhsa04110:Cell cycle
|
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MicroRNAs in cancer
|
|
NetPath Pathway
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IL2 Signaling Pathway
|
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TGF_beta_Receptor Signaling Pathway
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Wnt Signaling PathwayNetPath_16:IL4 Signaling Pathway
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Pathway Interaction Database
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PLK1 signaling events
|
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FOXM1 transcription factor network
|
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p38 signaling mediated by MAPKAP kinases
|
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Aurora A signalinge2f_pathway:E2F transcription factor network
|
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ATR signaling pathway
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Validated targets of C-MYC transcriptional activation
|
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ATM pathway
|
|
Reactome
|
Cyclin B2 mediated events
|
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Cyclin A/B1 associated events during G2/M transition
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Cyclin A:Cdk2-associated events at S phase entryR-HSA-113510:E2F mediated regulation of DNA replication
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G0 and Early G1
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Polo-like kinase mediated events
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Activation of ATR in response to replication stress
|
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Cyclin E associated events during G1/S transition
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G1/S-Specific Transcription
|
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Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
|
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Cyclin A:Cdk2-associated events at S phase entry
|
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WikiPathways
|
Senescence and Autophagy in Cancer
|
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MAPK Signaling Pathway
|
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Retinoblastoma (RB) in Cancer
|
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Prostate Cancer
|
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
|
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Mitotic G2-G2/M phases
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Cell CycleWP707:DNA Damage Response
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G1 to S cell cycle control
|
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S Phase
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ATM Signaling Pathway
|
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Mitotic G1-G1/S phases
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Cell Cycle
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Cell Cycle Checkpoints
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miRNAs involved in DNA damage response
|
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miRNA Regulation of DNA Damage Response
|
| References |
| REF 1 | Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4330-4. Epub 2009 May 27.Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. |
|---|
