Target Validation Information
Target ID T90648
Target Name mRNA of B-Raf
Target Type
Clinical Trial
Drug Potency against Target 2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine Drug Info IC50 = 12000 nM [527954]
2-(Benzylamino)-6-(3-acetamidophenyl)pyrazine Drug Info IC50 = 18000 nM [527954]
Pyrazolo[1,5-a]pyrimidine-3-carboxylate Drug Info IC50 = 1540 nM [530074]
ZM-336372 Drug Info IC50 = 230 nM [529039]
L-779450 Drug Info IC50 = 10 nM [527836]
References
Ref 527954J Med Chem. 2006 Jan 12;49(1):407-16.Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead.
Ref 527954J Med Chem. 2006 Jan 12;49(1):407-16.Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead.
Ref 530074Bioorg Med Chem Lett. 2009 May 15;19(10):2735-8. Epub 2009 Mar 28.Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.
Ref 527836Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. Epub 2005 Nov 2.The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.