| Drug General Information |
| Drug ID |
D01DDB
|
| Former ID |
DNC006065
|
| Drug Name |
2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H16N4O
|
| Canonical SMILES |
CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NC3=CC=CC=C3
|
| InChI |
1S/C18H16N4O/c1-13(23)20-16-9-5-6-14(10-16)17-11-19-12-18(22-17)21-15-7-3-2-4-8-15/h2-12H,1H3,(H,20,23)(H,21,22)
|
| InChIKey |
MKRMZWIJCMWBDU-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
mRNA of B-Raf |
Target Info |
Inhibitor |
[1]
|
|---|
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KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Rap1 signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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FoxO signaling pathway
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mTOR signaling pathway
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Vascular smooth muscle contraction
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Focal adhesion
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Natural killer cell mediated cytotoxicity
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Long-term potentiation
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Neurotrophin signaling pathway
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Serotonergic synapse
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Long-term depression
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Regulation of actin cytoskeleton
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Insulin signaling pathway
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Progesterone-mediated oocyte maturation
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Alcoholism
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Hepatitis C
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Pathways in cancer
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Proteoglycans in cancer
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Colorectal cancer
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Renal cell carcinoma
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Pancreatic cancer
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Endometrial cancer
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Glioma
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Prostate cancer
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Thyroid cancer
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
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Acute myeloid leukemia
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Non-small cell lung cancer
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NetPath Pathway
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IL-7 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Integrin signalling pathway
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Interleukin signaling pathway
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PDGF signaling pathway
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T cell activation
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VEGF signaling pathway
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Ras Pathway
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CCKR signaling map ST
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Pathway Interaction Database
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CDC42 signaling events
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mTOR signaling pathway
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Ras signaling in the CD4+ TCR pathway
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ErbB1 downstream signaling
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PDGFR-beta signaling pathway
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Signaling events mediated by VEGFR1 and VEGFR2
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Trk receptor signaling mediated by the MAPK pathway
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Reactome
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Spry regulation of FGF signaling
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Frs2-mediated activation
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ARMS-mediated activation
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CREB phosphorylation through the activation of Ras
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RAF activation
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MAP2K and MAPK activation
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Negative feedback regulation of MAPK pathway
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Negative regulation of MAPK pathway
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WikiPathways
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Serotonin Receptor 4/6/7 and NR3C Signaling
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Serotonin HTR1 Group and FOS Pathway
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Senescence and Autophagy in Cancer
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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MAPK Cascade
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MAPK Signaling Pathway
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Bladder Cancer
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Polycystic Kidney Disease Pathway
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Corticotropin-releasing hormone
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B Cell Receptor Signaling Pathway
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Signaling Pathways in Glioblastoma
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Integrated Breast Cancer Pathway
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Signaling by FGFR
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NGF signalling via TRKA from the plasma membrane
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Integrin-mediated Cell Adhesion
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| References |
| REF 1 | J Med Chem. 2006 Jan 12;49(1):407-16.Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead. |
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