| Drug General Information |
| Drug ID |
D06WJA
|
| Former ID |
DNC006033
|
| Drug Name |
L-779450
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H14ClN3O
|
| Canonical SMILES |
C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC(=C(C=C4)Cl)O
|
| InChI |
1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
|
| InChIKey |
WXJLXRNWMLWVFB-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Mitogen-activated protein kinase 14 |
Target Info |
Inhibitor |
[1]
|
|---|
| Mitogen-activated protein kinase 11 |
Target Info |
Inhibitor |
[1]
|
| Lck tyrosine kinase |
Target Info |
Inhibitor |
[1]
|
| Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[1]
|
| mRNA of B-Raf |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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MAPK signaling pathway
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Rap1 signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Osteoclast differentiation
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Leukocyte transendothelial migration
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
|
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Amyotrophic lateral sclerosis (ALS)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Leishmaniasis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Influenza A
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Epstein-Barr virus infection
|
|
Proteoglycans in cancerhsa04010:MAPK signaling pathway
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Proteoglycans in cancerhsa04064:NF-kappa B signaling pathway
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Natural killer cell mediated cytotoxicity
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HTLV-I infection
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Primary immunodeficiencyhsa04012:ErbB signaling pathway
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Chemokine signaling pathway
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Cell cycle
|
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PI3K-Akt signaling pathway
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Wnt signaling pathway
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Hedgehog signaling pathway
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Axon guidance
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Hippo signaling pathway
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Focal adhesion
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B cell receptor signaling pathway
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Insulin signaling pathway
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Melanogenesis
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Thyroid hormone signaling pathway
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Non-alcoholic fatty liver disease (NAFLD)
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Alzheimer's disease
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Measles
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Pathways in cancer
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Colorectal cancer
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Endometrial cancer
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Prostate cancer
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Basal cell carcinomahsa04010:MAPK signaling pathway
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ErbB signaling pathway
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cAMP signaling pathway
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mTOR signaling pathway
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Vascular smooth muscle contraction
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Long-term potentiation
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Serotonergic synapse
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Long-term depression
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Regulation of actin cytoskeleton
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Alcoholism
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Proteoglycans in cancer
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Renal cell carcinoma
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Pancreatic cancer
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Glioma
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Thyroid cancer
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
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Acute myeloid leukemia
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Non-small cell lung cancer
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NetPath Pathway
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IL5 Signaling Pathway
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FSH Signaling Pathway
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TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
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IL2 Signaling PathwayNetPath_19:IL-7 Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Angiogenesis
|
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B cell activation
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EGF receptor signaling pathway
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FGF signaling pathway
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Interferon-gamma signaling pathway
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Oxidative stress response
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Parkinson disease
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TGF-beta signaling pathway
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Toll receptor signaling pathway
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VEGF signaling pathway
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Ras Pathway
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p53 pathway feedback loops 2
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p38 MAPK pathway
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CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
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p38 MAPK pathwayP00049:Parkinson disease
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T cell activationP00004:Alzheimer disease-presenilin pathway
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Cadherin signaling pathway
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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Wnt signaling pathway
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CCKR signaling map STP00005:Angiogenesis
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Integrin signalling pathway
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T cell activation
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CCKR signaling map ST
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Pathway Interaction Database
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Endothelins
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BCR signaling pathway
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p73 transcription factor network
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p38 MAPK signaling pathway
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Atypical NF-kappaB pathway
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IL4-mediated signaling events
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CD40/CD40L signaling
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IL12-mediated signaling events
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Regulation of p38-alpha and p38-beta
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CDC42 signaling events
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Angiopoietin receptor Tie2-mediated signaling
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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Regulation of Androgen receptor activity
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ATF-2 transcription factor network
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IL6-mediated signaling events
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p38 signaling mediated by MAPKAP kinases
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Retinoic acid receptors-mediated signaling
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CXCR3-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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EPO signaling pathway
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Signaling events mediated by VEGFR1 and VEGFR2
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p53 pathway
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S1P2 pathway
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Trk receptor signaling mediated by the MAPK pathway
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VEGFR3 signaling in lymphatic endothelium
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FGF signaling pathway
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RAC1 signaling pathway
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Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
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Plasma membrane estrogen receptor signaling
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Regulation of retinoblastoma proteinnfkappabatypicalpathway:Atypical NF-kappaB pathway
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Glypican 1 network
|
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TCR signaling in naï
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Signaling events mediated by PTP1B
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TCR signaling in naï
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SHP2 signaling
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CXCR4-mediated signaling events
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Class I PI3K signaling events
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IL2 signaling events mediated by PI3K
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amb2 Integrin signaling
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EPHA forward signaling
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PDGFR-beta signaling pathway
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IL2 signaling events mediated by STAT5
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Ephrin B reverse signaling
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Alpha-synuclein signalinglysophospholipid_pathway:LPA receptor mediated events
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Degradation of beta catenin
|
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Reelin signaling pathway
|
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Presenilin action in Notch and Wnt signaling
|
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Integrin-linked kinase signaling
|
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LKB1 signaling events
|
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Canonical Wnt signaling pathway
|
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C-MYC pathway
|
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BMP receptor signaling
|
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Hedgehog signaling events mediated by Gli proteins
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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Validated transcriptional targets of deltaNp63 isoforms
|
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Aurora A signaling
|
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Insulin-mediated glucose transport
|
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Class I PI3K signaling events mediated by Akt
|
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Trk receptor signaling mediated by PI3K and PLC-gammacdc42_pathway:CDC42 signaling events
|
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mTOR signaling pathway
|
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Ras signaling in the CD4+ TCR pathway
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ErbB1 downstream signaling
|
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Reactome
|
NOD1/2 Signaling Pathway
|
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p38MAPK events
|
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ERK/MAPK targets
|
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Activation of PPARGC1A (PGC-1alpha) by phosphorylation
|
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Oxidative Stress Induced Senescence
|
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CDO in myogenesis
|
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DSCAM interactions
|
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ADP signalling through P2Y purinoceptor 1
|
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Platelet sensitization by LDL
|
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VEGFA-VEGFR2 Pathway
|
|
activated TAK1 mediates p38 MAPK activation
|
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Activation of the AP-1 family of transcription factors
|
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KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
|
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KSRP (KHSRP) binds and destabilizes mRNAR-HSA-114604:GPVI-mediated activation cascade
|
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PIP3 activates AKT signaling
|
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Regulation of KIT signaling
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Phosphorylation of CD3 and TCR zeta chains
|
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Translocation of ZAP-70 to Immunological synapse
|
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Generation of second messenger molecules
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PECAM1 interactions
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Constitutive Signaling by Aberrant PI3K in Cancer
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DAP12 signaling
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CD28 co-stimulation
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CD28 dependent PI3K/Akt signaling
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CD28 dependent Vav1 pathway
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CTLA4 inhibitory signaling
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PD-1 signaling
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Interleukin-2 signalingR-HSA-195253:Degradation of beta-catenin by the destruction complex
|
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AKT phosphorylates targets in the cytosol
|
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Regulation of HSF1-mediated heat shock response
|
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CRMPs in Sema3A signaling
|
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
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S33 mutants of beta-catenin aren't phosphorylated
|
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S37 mutants of beta-catenin aren't phosphorylated
|
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S45 mutants of beta-catenin aren't phosphorylated
|
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T41 mutants of beta-catenin aren't phosphorylated
|
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Degradation of GLI2 by the proteasome
|
|
Constitutive Signaling by AKT1 E17K in CancerR-HSA-1295596:Spry regulation of FGF signaling
|
|
Frs2-mediated activation
|
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ARMS-mediated activation
|
|
CREB phosphorylation through the activation of Ras
|
|
RAF activation
|
|
MAP2K and MAPK activation
|
|
Negative feedback regulation of MAPK pathway
|
|
Negative regulation of MAPK pathway
|
|
WikiPathways
|
Toll-like receptor signaling pathway
|
|
Monoamine Transport
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
TCR Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
Interferon type I signaling pathways
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
MAPK Cascade
|
|
Oxidative Stress
|
|
p38 MAPK Signaling Pathway
|
|
IL-4 Signaling Pathway
|
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MAPK Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
Kit receptor signaling pathway
|
|
Cardiac Hypertrophic Response
|
|
MAP kinase activation in TLR cascade
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
JAK/STAT
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Cardiac Progenitor Differentiation
|
|
BDNF signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Parkinsons Disease Pathway
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Prostate Cancer
|
|
TSLP Signaling Pathway
|
|
TWEAK Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
|
IL-1 signaling pathway
|
|
Signal amplification
|
|
Platelet homeostasis
|
|
NGF signalling via TRKA from the plasma membrane
|
|
Myogenesis
|
|
DSCAM interactions
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Angiogenesis
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
|
|
Regulation of toll-like receptor signaling pathwayWP61:Notch Signaling Pathway
|
|
IL-2 Signaling Pathway
|
|
Inflammatory Response Pathway
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Host Interactions of HIV factors
|
|
PIP3 activates AKT signaling
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
TCR signaling
|
|
Costimulation by the CD28 familyWP710:DNA Damage Response (only ATM dependent)
|
|
Notch Signaling Pathway
|
|
Glycogen Metabolism
|
|
Wnt Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
IL-6 signaling pathway
|
|
Wnt Signaling Pathway Netpath
|
|
Copper homeostasis
|
|
Focal Adhesion
|
|
Hair Follicle Development: Induction (Part 1 of 3)
|
|
Degradation of beta-catenin by the destruction complex
|
|
IL17 signaling pathway
|
|
Neural Crest Differentiation
|
|
Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
Semaphorin interactions
|
|
Cell Cycle
|
|
Androgen receptor signaling pathway
|
|
IL-5 Signaling PathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Regulation of Actin Cytoskeleton
|
|
Bladder Cancer
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Polycystic Kidney Disease Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Integrated Breast Cancer Pathway
|
|
Signaling by FGFR
|
|
Integrin-mediated Cell Adhesion
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. Epub 2005 Nov 2.The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. |
|---|
