| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T59045 | ||||
| Target Name | 4-aminobutyrate aminotransferase, mitochondrial | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 4-hydroxybenzaldehyde | Drug Info | IC50 = 16500 nM | [529916] | |
| L-Alanine | Drug Info | Ki = 160000 nM | [552856] | ||
| 4-hydroxybenzylamine | Drug Info | IC50 = 15400 nM | [527869] | ||
| 4-hydroxy-3-nitrobenzaldehyde | Drug Info | IC50 = 15500 nM | [527869] | ||
| 1-(4-hydroxyphenyl)prop-2-en-1-one | Drug Info | IC50 = 5480 nM | [527869] | ||
| 3-chloro-1-(4-hydroxyphenyl)propan-1-one | Drug Info | IC50 = 3990 nM | [529916] | ||
| VANILLIN | Drug Info | IC50 = 17100 nM | [527869] | ||
| References | |||||
| Ref 529916 | Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4. Epub 2008 Dec 11.Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. | ||||
| Ref 552856 | Inhibitors of glutamine synthetase and their potential application in medicine. Mini Rev Med Chem. 2008 Aug;8(9):869-78. | ||||
| Ref 527869 | Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. | ||||
| Ref 527869 | Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. | ||||
| Ref 527869 | Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. | ||||
| Ref 529916 | Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4. Epub 2008 Dec 11.Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. | ||||
| Ref 527869 | Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. | ||||
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