| Drug General Information |
| Drug ID |
D0L7RB
|
| Former ID |
DNC006145
|
| Drug Name |
1-(4-hydroxyphenyl)prop-2-en-1-one
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H8O2
|
| Canonical SMILES |
C=CC(=O)C1=CC=C(C=C1)O
|
| InChI |
1S/C9H8O2/c1-2-9(11)7-3-5-8(10)6-4-7/h2-6,10H,1H2
|
| InChIKey |
NKPPNPJUBLEKAD-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
4-aminobutyrate aminotransferase, mitochondrial |
Target Info |
Inhibitor |
[1]
|
|---|
| Succinate semialdehyde dehydrogenase, mitochondrial |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
GABA shunt
|
|
Valine degradation
|
|
Beta-alanine degradation
|
|
4-aminobutyrate degradationGLUDEG-I-PWY:GABA shunt
|
|
4-aminobutyrate degradation
|
|
KEGG Pathway
|
Alanine, aspartate and glutamate metabolism
|
|
Valine, leucine and isoleucine degradation
|
|
beta-Alanine metabolism
|
|
Propanoate metabolism
|
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Butanoate metabolism
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Metabolic pathways
|
|
GABAergic synapsehsa00250:Alanine, aspartate and glutamate metabolism
|
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PANTHER Pathway
|
Aminobutyrate degradation
|
|
Pyrimidine Metabolism
|
|
Gamma-aminobutyric acid synthesisP02726:Aminobutyrate degradation
|
|
Gamma-aminobutyric acid synthesis
|
|
PathWhiz Pathway
|
Aspartate Metabolism
|
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Glutamate Metabolism
|
|
Beta-Alanine Metabolism
|
|
Valine, Leucine and Isoleucine Degradation
|
|
Propanoate MetabolismPW000003:Glutamate Metabolism
|
|
WikiPathways
|
GABA synthesis, release, reuptake and degradation
|
|
Alanine and aspartate metabolismWP2685:GABA synthesis, release, reuptake and degradation
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. |
|---|
