Target Information

Target General Infomation
Target ID
T13259
Former ID
TTDS00054
Target Name
Succinate semialdehyde dehydrogenase, mitochondrial
Gene Name
ALDH5A1
Synonyms
NAD(+)-dependent succinic semialdehyde dehydrogenase; Succinic dehydrogenase; ALDH5A1
Target Type
Successful
Disease Dietary shortage [ICD9: 260-269; ICD10: E40-E46]
Diagnostic imaging [ICD9: 331; ICD10: G30, I73.9]
Function
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
BioChemical Class
Oxidoreductases acting on aldehyde or oxo group of donors
Target Validation
T13259
UniProt ID
P51649
EC Number
EC 1.2.1.24
Sequence
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV
KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF
AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF
EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR
VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
Drugs and Mode of Action
Drug(s) Chlormerodrin Drug Info Approved Diagnostic imaging [550714]
Succinic acid Drug Info Approved Dietary shortage [540490], [544502]
Inhibitor 1-(4-hydroxyphenyl)prop-2-en-1-one Drug Info [527869]
Succinic acid Drug Info [536076], [536268], [537159]
VANILLIN Drug Info [527869]
Modulator Chlormerodrin Drug Info [556264]
Pathways
BioCyc Pathway GABA shunt
4-aminobutyrate degradation
KEGG Pathway Alanine, aspartate and glutamate metabolism
Butanoate metabolism
Metabolic pathways
PANTHER Pathway Aminobutyrate degradation
Gamma-aminobutyric acid synthesis
PathWhiz Pathway Glutamate Metabolism
WikiPathways GABA synthesis, release, reuptake and degradation
References
Ref 540490(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3637).
Ref 544502Handbook of Food Analysis: Residues and other food component analysis. 2006, P914. By Leo M. L. Nollet.
Ref 550714Drug information of Chlormerodrin, 2008. eduDrugs.
Ref 527869Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.
Ref 536076The GABA shunt: an attractive and potential therapeutic target in the treatment of epileptic disorders. Curr Drug Metab. 2005 Apr;6(2):127-39.
Ref 536268Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens. Mol Microbiol. 2006 Oct;62(1):45-56. Epub 2006 Aug 30.
Ref 537159Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. Epub 2009 Mar 19.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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