Target General Infomation
Target ID
T72779
Former ID
TTDR00983
Target Name
Maspin
Gene Name
SERPINB5
Synonyms
Protease inhibitor 5; SERPINB5
Target Type
Research
Function
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
BioChemical Class
Serpin family
UniProt ID
Sequence
MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHF
ENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVD
FKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESET
KECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDES
TGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSED
TSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRH
NKTRNIIFFGKFCSP
Inhibitor S,S-(2-Hydroxyethyl)Thiocysteine Drug Info [551393]
Pathways
KEGG Pathway p53 signaling pathway
MicroRNAs in cancer
PANTHER Pathway p53 pathway
Pathway Interaction Database Direct p53 effectors
ATF-2 transcription factor network
Validated transcriptional targets of TAp63 isoforms
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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