Target Information
Target General Infomation | |||||
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Target ID |
T70680
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Former ID |
TTDS00504
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Target Name |
Organic anion transporter 1
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Gene Name |
SLC22A8
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Synonyms |
OAT1; PAH transporter; PAHT; Renal organic anion transporter 1; SLC22A6; Solute carrier family 22 member 6; hOAT1; hPAHT; hROAT1; SLC22A8
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Target Type |
Successful
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Disease | Gout; Hyperuricemia [ICD9: 274, 790.6; ICD10: E79.0, M10] | ||||
Obesity [ICD9: 278; ICD10: E66] | |||||
Ocular disease [ICD10: H00-H59] | |||||
Function |
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc).
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BioChemical Class |
Major facilitator superfamily
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Target Validation |
T70680
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UniProt ID | |||||
Sequence |
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG SS |
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Drugs and Mode of Action | |||||
Pathways | |||||
PathWhiz Pathway | Kidney Function | ||||
References | |||||
Ref 467694 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4357). | ||||
Ref 538403 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 007898. | ||||
Ref 528881 | J Biol Chem. 2007 Aug 17;282(33):23841-53. Epub 2007 Jun 5.Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. |
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