Drug Information

Drug General Information
Drug ID
D0L7FM
Former ID
DAP001292
Drug Name
Probenecid
Synonyms
Apurina; Bencid; Benecid; Benemid; Benemide; Benuryl; Panuric; Parabenem; Probalan; Probampacin; Probecid; Proben; Probenecida; Probenecide; Probenecidum; Probenemid; Probenicid; Probenid; Probexin; Prolongine; Robenecid; Sulprin; Tubophan; Uricosid; Urocid; Biokanol Brand of Probenecid; ICN Brand of Probenecid; IDIS Brand of Probenecid; Major Brand of Probenecid; Martec Brand of Probenecid; Merck Brand of Probenecid; Ophthalmic Brand of Probenecid; Parmed Brand of Probenecid; Probenecid Major Brand; Probenecid Martec Brand; Probenecid Parmed Brand; Probenecid Weimer; Probenecid Zenith Brand; Probenecid acid; Synergid R; Valdecasas Brand of Probenecid; Zenith Brand of Probenecid; Benemid (TN); Benuryl (TN); Col-BENEMID; ColBenemid (co mponent of); ColBenemid (component of); P-[Dipropylsulfamoyl]benzoic acid; Polycillin-BRB; Pro-Cid; Probenecida [INN-Spanish]; Probenecide [INN-French]; Probenecidum [INN-Latin]; P-(Dipropylsulfamoyl)benzoic acid; P-(Dipropylsulfamyl)benzoic acid; Polycillin-PRB (component of); Probenecid [INN:BAN:JAN]; Probenecid (JP15/USP/INN); 4-((Dipropylamino)sulfonyl)benzoic acid;4-(Di-n-propylsulfamoyl)benzoesaeure; 4-(Dipropylsulfamoyl)benzoic acid; 4-(N,N-Dipropylsulfamoyl)benzoesaeure; 4-[(dipropylamino)sulfonyl]benzoic acid
Drug Type
Small molecular drug
Indication Gout; Hyperuricemia [ICD9: 274, 790.6; ICD10:E79.0, M10] Approved [467694], [538403], [551871]
Therapeutic Class
Uricosuric Agents
Structure
Download
2D MOL

3D MOL
Formula
C13H19NO4S
InChI
InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
InChIKey
DBABZHXKTCFAPX-UHFFFAOYSA-N
CAS Number
CAS 57-66-9
PubChem Compound ID
4911
PubChem Substance ID
9576, 81789, 855953, 3162120, 5227618, 7847541, 7980385, 8149496, 8153022, 10321755, 10528000, 11112135, 11335231, 11360470, 11363728, 11366290, 11368852, 11371827, 11374110, 11377014, 11461442, 11466570, 11467690, 11485063, 11486240, 11489110, 11490370, 11492301, 11494648, 14873183, 17389752, 24898976, 26611889, 26680013, 26747055, 26747056, 26751571, 29223989, 46506554, 47588826, 47662104, 47885248, 47959564, 47959565, 48034940, 48110289, 48334309, 48414371, 48416470, 48423998
SuperDrug ATC ID
M04AB01
SuperDrug CAS ID
cas=000057669
Target and Pathway
Target(s) Organic anion transporter 1 Target Info Blocker [535702], [537720]
PathWhiz Pathway Kidney Function
References
Ref 467694(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4357).
Ref 538403FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 007898.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535702Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158. Epub 2003 Jan 30.
Ref 537720Interactions of organic anions with the organic cation transporter in renal BBMV. Am J Physiol. 1988 Jan;254(1 Pt 2):F56-61.

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