Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T56367
|
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| Former ID |
TTDS00167
|
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| Target Name |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1
|
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| Synonyms |
61 kDa Cam-PDE; Cam-PDE 1; Cam-PDE 1A; HCam-1; PDE-I
|
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| Target Type |
Successful
|
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| Disease | Acute ischemic stroke [ICD9: 434.91; ICD10: I61-I63] | ||||
| Function |
Has a higher affinity for cgmp than for camp.
|
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| BioChemical Class |
Phosphoric diester hydrolases
|
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| Target Validation |
T56367
|
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| EC Number |
EC 3.1.4.17
|
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| Drugs and Mode of Action | |||||
| Drug(s) | Vinpocetine | Drug Info | Approved | Acute ischemic stroke | [1], [2] |
| ZAPRINAST | Drug Info | Terminated | Discovery agent | [3], [4] | |
| Inhibitor | 3-Isobutyl-1-methyl-3,9-dihydro-purine-2,6-dione | Drug Info | [5] | ||
| BUFROLIN | Drug Info | [5] | |||
| S,S-(2-Hydroxyethyl)Thiocysteine | Drug Info | [6] | |||
| Vinpocetine | Drug Info | [1] | |||
| ZAPRINAST | Drug Info | [7] | |||
| References | |||||
| REF 1 | Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue. Urology. 2009 Jun;73(6):1397-401. Epub 2009 Mar 13. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5285). | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2919). | ||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000060) | ||||
| REF 5 | J Med Chem. 1985 May;28(5):537-45.A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. | ||||
| REF 6 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 7 | J Med Chem. 2005 May 19;48(10):3449-62.The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. | ||||
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