Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T28043
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| Former ID |
TTDI03519
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| Target Name |
ribosomal protein S6 kinase, 90kDa, polypeptide 2
|
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| Gene Name |
RPS6KA2
|
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| Synonyms |
RPS6KA2
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| Target Type |
Research
|
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| Disease | Chronic lymphocytic leukaemia [ICD10: C91] | ||||
| UniProt ID | |||||
| Sequence |
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE
LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA QRRGMKRLTSTRL |
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| Drugs and Mode of Action | |||||
| Drug(s) | BI-D1870 | Drug Info | Preclinical | Chronic lymphocytic leukaemia | [1] |
| Inhibitor | BI-D1870 | Drug Info | [1] | ||
| compound 25b | Drug Info | [2] | |||
| References | |||||
| REF 1 | BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38. | ||||
| REF 2 | Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. | ||||
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