Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T17426
|
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| Former ID |
TTDR00042
|
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| Target Name |
Beta-hydroxyacyl-acp dehydratase
|
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| Gene Name |
PF3D7_1323000
|
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| Synonyms |
FabZ; PF3D7_1323000
|
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| Target Type |
Research
|
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| BioChemical Class |
Carbon-oxygen lyases
|
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| Target Validation |
T17426
|
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| UniProt ID | |||||
| EC Number |
EC 4.2.1.-
|
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| Sequence |
MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDV
SSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGL KQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWK KPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK |
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| Inhibitor | (-)-CATECHINGALLATE | Drug Info | [1] | ||
| 2-Hexadecynoic acid | Drug Info | [2] | |||
| BIOCHANIN | Drug Info | [1] | |||
| EPIGALOCATECHIN GALLATE | Drug Info | [1] | |||
| FISETIN | Drug Info | [1] | |||
| GALLOCATECHIN GALLATE | Drug Info | [1] | |||
| MORIN | Drug Info | [1] | |||
| Pathways | |||||
| KEGG Pathway | Fatty acid biosynthesis | ||||
| Biotin metabolism | |||||
| Metabolic pathways | |||||
| Fatty acid metabolism | |||||
| References | |||||
| REF 1 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| REF 2 | Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. | ||||
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