Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T15851
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| Former ID |
TTDR00231
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| Target Name |
Orotidine 5'-monophosphate decarboxylase
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| Gene Name |
UMPS
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| Synonyms |
OMP decarboxylase; OMPDCase; OMPdecase; Orotidine decarboxylase; UMPS
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| Target Type |
Research
|
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| BioChemical Class |
Pentosyltransferase
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| Target Validation |
T15851
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| UniProt ID | |||||
| EC Number |
EC 4.1.1.23
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| Sequence |
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV |
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| Structure |
1ORO; 2EAW; 2JGY; 2P1F; 2QCC; 2QCD; 2QCE; 2QCF; 2QCG; 2QCH; 2QCL; 2QCM; 2QCN; 2V30; 2WNS; 3BGG; 3BGJ; 3BK0; 3BVJ; 3DBP; 3EWU; 3EWW; 3EWX; 3EWY; 3EWZ; 3EX1; 3EX2; 3EX3; 3EX4; 3EX6; 3G3D; 3G3M; 3L0K; 3L0N; 3MI2; 3MO7; 3MW7; 4HIB; 4HKP
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| Inhibitor | 5-fluoro-6-amino-UMP | Drug Info | [1] | ||
| 5-fluoro-6-azido-UMP | Drug Info | [1] | |||
| 5-Fluoro-6-ethyluridine-5'-O-monophosphate | Drug Info | [1] | |||
| 5-fluoro-6-iodo-UMP | Drug Info | [1] | |||
| 6-Hydroxyuridine-5'-Phosphate | Drug Info | [2] | |||
| Alpha-Phosphoribosylpyrophosphoric Acid | Drug Info | [3] | |||
| Pyrazofurin | Drug Info | [4] | |||
| Pathways | |||||
| BioCyc Pathway | Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | ||||
| Superpathway of pyrimidine ribonucleotides de novo biosynthesis | |||||
| UMP biosynthesis | |||||
| KEGG Pathway | Pyrimidine metabolism | ||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathways | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | Pyrimidine biosynthesis | ||||
| WikiPathways | Metabolism of nucleotides | ||||
| Fluoropyrimidine Activity | |||||
| References | |||||
| REF 1 | J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. | ||||
| REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 3 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
| REF 4 | Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75. | ||||
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