Drug Information

Drug General Information
Drug ID
D08OFS
Former ID
DNC009674
Drug Name
5-fluoro-6-azido-UMP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529995]
Structure
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2D MOL

3D MOL
Formula
C9H11FN5O9P
Canonical SMILES
C(C1C(C(C(O1)N2C(=C(C(=O)NC2=O)F)N=[N+]=[N-])O)O)OP(=O)<br />(O)O
InChI
1S/C9H11FN5O9P/c10-3-6(13-14-11)15(9(19)12-7(3)18)8-5(17)4(16)2(24-8)1-23-25(20,21)22/h2,4-5,8,16-17H,1H2,(H,12,18,19)(H2,20,21,22)/t2-,4-,5-,8-/m1/s1
InChIKey
ARRBQQMKVQEOHQ-UMMCILCDSA-N
PubChem Compound ID
16666489
Target and Pathway
Target(s) Orotidine 5'-monophosphate decarboxylase Target Info Inhibitor [529995]
BioCyc Pathway Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine ribonucleotides de novo biosynthesis
UMP biosynthesis
KEGG Pathway Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 529995J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
Ref 529995J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.

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