Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T14582
|
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| Former ID |
TTDR00158
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| Target Name |
Alanine racemase,biosynthetic
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| Gene Name |
alr
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| Synonyms |
AlaR; Alanine racemase; Alr; D-alanine racemase; alr
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| Target Type |
Research
|
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| Function |
Catalyzes the interconversion of L-alanine and D- alanine. Overexpression due to a natural mutation in the promoter is responsible for mediating resistance to D-cycloserine (DCS) in mycobacteria.
|
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| BioChemical Class |
Racemases and epimerases
|
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| UniProt ID | |||||
| EC Number |
EC 5.1.1.1
|
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| Sequence |
MQTTEPMTPPAPLASAQTVIDLGAIDHNVRVLRELAGSADVMAVVKADAYGHGALPVART
ALAAGAAALGVATIPEALALREGGITAPVLAWLHPPGTDFAPAIAADVEVAVSSRRQLEQ VTAAAAEVGRTATVTVKVDTGLSRNGVGAADYPEVLDVLRRAQADGAIRVRGLMSHLVHG DDPENPFNGLQGQRLADMRVYAREHGVDYEVAHLCNSPAAMTRPDLAFEMVRPGISLYGL SPIPERGDMGLRPAMTLKCPVALVRSVHAGDGVSYGHRWVADRDTTLGLLPIGYADGVYR ALSGRIDVLIKGRRRRAVGRICMDQFVVDLGPDADDVAVGDDAILFGPGANGEPTAQDWA ELLDTIHYEVVTSPRGRVTRTYLPAGQQD |
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| Inhibitor | (R)-4-Amino-Isoxazolidin-3-One | Drug Info | [1] | ||
| 3-fluorovinylglycine | Drug Info | [2] | |||
| Acetate Ion | Drug Info | [1] | |||
| Lysine Nz-Carboxylic Acid | Drug Info | [1] | |||
| N-(5'-Phosphopyridoxyl)-D-Alanine | Drug Info | [1] | |||
| Propanoic Acid | Drug Info | [1] | |||
| Propionate | Drug Info | [3] | |||
| Pyridoxamine-5'-Phosphate | Drug Info | [1] | |||
| Pyridoxyl-Alanine-5-Phosphate | Drug Info | [1] | |||
| Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate | Drug Info | [1] | |||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | Mechanism-based inactivation of alanine racemase by 3-halovinylglycines. J Biol Chem. 1991 Nov 15;266(32):21657-65. | ||||
| REF 3 | Molecular dynamics studies of alanine racemase: a structural model for drug design. Biopolymers. 2003 Oct;70(2):186-200. | ||||
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