Drug Information

Drug General Information
Drug ID
D0VA2I
Former ID
DCL000095
Drug Name
CRx-191
Indication Psoriatic disorder [ICD9: 696; ICD10:L40] Discontinued in Phase 2 [548453]
Company
CombinatoRx
Target and Pathway
Target(s) Interferon gamma Target Info Inhibitor [551126]
Tumor necrosis factor Target Info Inhibitor [551126]
KEGG Pathway Proteasome
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Regulation of autophagy
TGF-beta signaling pathway
Osteoclast differentiation
Antigen processing and presentation
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Type I diabetes mellitus
Salmonella infection
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Inflammatory bowel disease (IBD)
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host diseasehsa04010:MAPK signaling pathway
NF-kappa B signaling pathway
Sphingolipid signaling pathway
mTOR signaling pathway
Apoptosis
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Hematopoietic cell lineage
Fc epsilon RI signaling pathway
TNF signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Pertussis
Legionellosis
Hepatitis C
Hepatitis B
HTLV-I infection
Proteoglycans in cancer
Asthma
Graft-versus-host disease
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy
NetPath Pathway IL1 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
Leptin Signaling PathwayNetPath_11:TCR Signaling Pathway
IL3 Signaling Pathway
IL4 Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interferon-gamma signaling pathwayP00006:Apoptosis signaling pathway
Wnt signaling pathway
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
SHP2 signaling
Regulation of Telomerase
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
IFN-gamma pathway
ATF-2 transcription factor network
AP-1 transcription factor network
IL23-mediated signaling events
PDGFR-alpha signaling pathway
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4il27pathway:IL27-mediated signaling events
Canonical NF-kappaB pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by HDAC Class I
TNF receptor signaling pathway
Ceramide signaling pathway
amb2 Integrin signaling
RXR and RAR heterodimerization with other nuclear receptor
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Cellular roles of Anthrax toxin
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Interferon gamma signaling
Regulation of IFNG signalingR-HSA-381340:Transcriptional regulation of white adipocyte differentiation
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFR2 non-canonical NF-kB pathway
TNF signaling
WikiPathways Type II interferon signaling (IFNG)
Senescence and Autophagy in Cancer
TGF Beta Signaling Pathway
Cytokines and Inflammatory Response
Hypertrophy Model
Inflammatory Response Pathway
Aryl Hydrocarbon Receptor Pathway
IL1 and megakaryotyces in obesity
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Spinal Cord Injury
Allograft Rejection
Interferon gamma signaling
Proteasome Degradation
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP75:Toll-like receptor signaling pathway
Monoamine Transport
SIDS Susceptibility Pathways
MAPK Signaling Pathway
EV release from cardiac cells and their functional effects
FAS pathway and Stress induction of HSP regulation
Apoptosis-related network due to altered Notch3 in ovarian cancer
Cardiac Hypertrophic Response
Transcriptional Regulation of White Adipocyte Differentiation
Aryl Hydrocarbon Receptor
Apoptosis
Nanoparticle triggered regulated necrosis
Amyotrophic lateral sclerosis (ALS)
Adipogenesis
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
Extrinsic Pathway for Apoptosis
MicroRNAs in cardiomyocyte hypertrophy
Selenium Micronutrient Network
Regulation of toll-like receptor signaling pathway
Matrix Metalloproteinases
References
Ref 548453Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025635)
Ref 551126CombinatoRx Drug Candidate CRx-191 Demonstrates Positive Phase 2 Results In Psoriasis. CombinatoRx. 2008.

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