Drug General Information
Drug ID	D02REM
Former ID	DIB003361
Drug Name	DPI-221
Indication	Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32]		Investigative	[543762]
Company	Ardent Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[C@@H](N1[C@H](CN([C@@H](C1)C)Cc1cc(ccc1)F)C)(c1ccc(cc1<br />)C(=O)N(CC)CC)c1ccccc1
Target and Pathway
Target(s)	Delta-type opioid receptor	Target Info	Agonist	[543762]
KEGG Pathway	cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
	Opioid proenkephalin pathway
	Opioid proopiomelanocortin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543762	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).
Ref 543762	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).

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