Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00QGB
|
||||
| Former ID |
DIB014693
|
||||
| Drug Name |
O-2442
|
||||
| Synonyms |
DAT specific inhibitors, Organix; Dopamine transporter modulator, Organix; O-2442; O-2443; O-2642; O-506; O-509
|
||||
| Indication | Cocaine addiction [ICD9: 304.2; ICD10:F14.2] | Investigative | [1] | ||
| Company |
Organix Inc
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
C1(=C(c2cc(c(cc2)Cl)Cl)C[C@@H]2CC[C@H]1S2)C(=O)OC
|
||||
| CAS Number |
CAS 174643-75-5
|
||||
| Target and Pathway | |||||
| Target(s) | Sodium-dependent dopamine transporter | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Dopaminergic synapse | ||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Parkinson disease | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Dopaminergic Neurogenesis | |||||
| Parkinsons Disease Pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| Neurotransmitter Clearance In The Synaptic Cleft | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.