Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S7IZ
|
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| Former ID |
DNCL002633
|
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| Drug Name |
Apricoxib
|
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| Synonyms |
TG01
|
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| Drug Type |
Small molecular drug
|
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| Indication | Non-small cell lung cancer; Pancreatic cancer; Rheumatoid arthritis [ICD9: 140-199, 140-229, 157, 210-229, 710-719, 714; ICD10:C33-C34, C25, M05-M06] | Discontinued in Phase 2 | [548493] | ||
| Company |
Tragara Pharmaceuticals
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H20N2O3S
|
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| Canonical SMILES |
CCOC1=CC=C(C=C1)C2=CC(=CN2C3=CC=C(C=C3)S(=O)(=O)N)C
|
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| InChI |
1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23)
|
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| InChIKey |
JTMITOKKUMVWRT-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Prostaglandin G/H synthase 2 | Target Info | Inhibitor | [530463] | |
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| NF-kappa B signaling pathway | |||||
| VEGF signaling pathway | |||||
| TNF signaling pathway | |||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Oxytocin signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Leishmaniasis | |||||
| Pathways in cancer | |||||
| Chemical carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| Small cell lung cancer | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| References | |||||
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