Drug Information

Drug General Information
Drug ID
D0U3EP
Former ID
DCL000234
Drug Name
SRT501
Synonyms
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol; (E)-5-(p-Hydroxystyryl)resorcinol; (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol; (E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzendiol; (E)-resveratrol; 3,4',5-Stilbenetriol; 3,4',5-Trihydroxy-trans-stilbene; 3,4',5-Trihydroxystilbene; 3,4',5-trihydroxy-stilbene; 3,5,4'-Trihydroxy-trans-stilbene; 3,5,4'-Trihydroxystilbene; 5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol; 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol; 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol; 5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol; 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
Drug Type
Small molecular drug
Indication Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Discontinued in Phase 2 [547718]
Company
Sirtris Pharma
Structure
Download
2D MOL

3D MOL
Formula
C14H12O3
Canonical SMILES
C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
InChI
1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
InChIKey
LUKBXSAWLPMMSZ-OWOJBTEDSA-N
CAS Number
CAS 375823-41-9
PubChem Compound ID
445154
PubChem Substance ID
6374, 458391, 584207, 611168, 837578, 855986, 866574, 7890614, 8145576, 10299643, 10321586, 11537676, 12015089, 14822845, 17388746, 17405667, 22388006, 24278055, 24715042, 24860876, 26512266, 26612338, 26679661, 26697115, 26736772, 26747076, 26747077, 26751586, 26751587, 26759440, 29204531, 36887952, 46386962, 46493745, 46504705, 47291249, 47515445, 47589112, 47959898, 48035263, 48035264, 48185110, 48185111, 48334633, 48424038, 48425593, 49661756, 49698529, 49734167, 49833229
Target and Pathway
Target(s) Prostaglandin G/H synthase 1 Target Info Modulator [535926]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
Serotonergic synapse
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 547718Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018787)
Ref 535926Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004 May 21;279(21):22727-37. Epub 2004 Mar 12.

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