Drug Information
Drug General Information | |||||
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Drug ID |
D0W6KM
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Former ID |
DIB005600
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Drug Name |
Dasotraline
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Synonyms |
SEP-225289; SEP-289; Triple reuptake inhibitors (depression), Sepracor
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Drug Type |
Small molecular drug
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Company |
Sunovion pharmaceuticals
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Structure |
Download2D MOL |
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Formula |
C16H15Cl2N
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InChI |
InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16+/m0/s1
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InChIKey |
SRPXSILJHWNFMK-MEDUHNTESA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Sodium-dependent dopamine transporter | Target Info | Inhibitor | [533235] | |
Sodium-dependent noradrenaline transporter | Target Info | Inhibitor | [533235] | ||
Sodium-dependent serotonin transporter | Target Info | Inhibitor | [533235] | ||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
Parkinson disease | |||||
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway | |||||
5HT2 type receptor mediated signaling pathway | |||||
5HT3 type receptor mediated signaling pathway | |||||
5HT4 type receptor mediated signaling pathway | |||||
Pathway Interaction Database | Alpha-synuclein signaling | ||||
WikiPathways | Monoamine Transport | ||||
NRF2 pathway | |||||
Dopaminergic Neurogenesis | |||||
Parkinsons Disease Pathway | |||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport | |||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport | |||||
SIDS Susceptibility Pathways | |||||
Synaptic Vesicle Pathway | |||||
Serotonin Transporter Activity | |||||
References | |||||
Ref 524969 | ClinicalTrials.gov (NCT02276209) Dasotraline Adult ADHD Study. U.S. National Institutes of Health. | ||||
Ref 543060 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8308). |
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