Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03DRR
|
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| Former ID |
DIB011193
|
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| Drug Name |
Noberastine
|
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| Synonyms |
Flamizole; R-64947; R-72075
|
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| Drug Type |
Small molecular drug
|
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| Indication | Asthma [ICD10:J45] | Phase 2 | [1] | ||
| Company |
Janssen Pharmaceutica NV
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H21N5O
|
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| Canonical SMILES |
n1(c(nc2c1nccc2)NC1CCNCC1)Cc1oc(cc1)C
|
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| CAS Number |
CAS 110588-56-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| Reactome | Histamine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| IL-4 Signaling Pathway | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001178) | ||||
| REF 2 | A double-blind placebo controlled dose response study of noberastine on histamine induced weal and flare. Eur J Clin Pharmacol. 1991;40(1):83-5. | ||||
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