Drug General Information
Drug ID	D01ZEY
Former ID	DIB011054
Drug Name	MDL-201112
Synonyms	Carbocyclic nucleoside, Hoechst; MDL-201449; MDL-201449A
Drug Type	Small molecular drug
Indication	Colitis [ICD9: 556.9; ICD10:K50-K52]		Terminated	[546299]
Company	Hoechst Marion Roussel Inc
Structure		Download 2D MOL 3D MOL
Formula	C10H13N5O
Canonical SMILES	n1(c2c(nc1)c(ncn2)N)[C@H]1C[C@@H](CC1)O
PubChem Compound ID	132408
Target and Pathway
Target(s)	Tumor necrosis factor	Target Info	Inhibitor	[533875]
KEGG Pathway	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	NF-kappa B signaling pathway
	Sphingolipid signaling pathway
	mTOR signaling pathway
	Apoptosis
	TGF-beta signaling pathway
	Osteoclast differentiation
	Antigen processing and presentation
	Toll-like receptor signaling pathway
	NOD-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Hematopoietic cell lineage
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	TNF signaling pathway
	Adipocytokine signaling pathway
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Type I diabetes mellitus
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Pertussis
	Legionellosis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	African trypanosomiasis
	Malaria
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Hepatitis C
	Hepatitis B
	Influenza A
	HTLV-I infection
	Herpes simplex infection
	Proteoglycans in cancer
	Asthma
	Inflammatory bowel disease (IBD)
	Systemic lupus erythematosus
	Rheumatoid arthritis
	Allograft rejection
	Graft-versus-host disease
	Hypertrophic cardiomyopathy (HCM)
	Dilated cardiomyopathy
NetPath Pathway	TCR Signaling Pathway
	IL2 Signaling Pathway
	IL3 Signaling Pathway
	IL4 Signaling Pathway
	Leptin Signaling Pathway
	RANKL Signaling Pathway
	IL1 Signaling Pathway
PANTHER Pathway	Apoptosis signaling pathway
	Wnt signaling pathway
Pathway Interaction Database	IL27-mediated signaling events
	Canonical NF-kappaB pathway
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Angiopoietin receptor Tie2-mediated signaling
	Signaling events mediated by HDAC Class I
	TNF receptor signaling pathway
	Ceramide signaling pathway
	amb2 Integrin signaling
	RXR and RAR heterodimerization with other nuclear receptor
	IL23-mediated signaling events
	HIV-1 Nef: Negative effector of Fas and TNF-alpha
	Caspase Cascade in Apoptosis
	Cellular roles of Anthrax toxin
	Downstream signaling in na&#xef
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
Reactome	Transcriptional regulation of white adipocyte differentiation
	TNFR1-induced proapoptotic signaling
	Regulation of TNFR1 signaling
	TNFR1-induced NFkappaB signaling pathway
	TNFR1-mediated ceramide production
	TNFR2 non-canonical NF-kB pathway
	TNF signaling
WikiPathways	Toll-like receptor signaling pathway
	Monoamine Transport
	SIDS Susceptibility Pathways
	TGF Beta Signaling Pathway
	Cytokines and Inflammatory Response
	MAPK Signaling Pathway
	EV release from cardiac cells and their functional effects
	FAS pathway and Stress induction of HSP regulation
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Cardiac Hypertrophic Response
	Transcriptional Regulation of White Adipocyte Differentiation
	Aryl Hydrocarbon Receptor
	Apoptosis
	Nanoparticle triggered regulated necrosis
	Amyotrophic lateral sclerosis (ALS)
	Adipogenesis
	Allograft Rejection
	TNF alpha Signaling Pathway
	TWEAK Signaling Pathway
	Extrinsic Pathway for Apoptosis
	Folate Metabolism
	MicroRNAs in cardiomyocyte hypertrophy
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	Regulation of toll-like receptor signaling pathway
	Matrix Metalloproteinases
References
Ref 546299	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007330)
Ref 533875	Effect of the carbocyclic nucleoside analogue MDL 201,112 on inhibition of interferon-gamma-induced priming of Lewis (LEW/N) rat macrophages for enhanced respiratory burst and MHC class II Ia+ antigen expression. J Leukoc Biol. 1994 Aug;56(2):133-44.

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