Drug General Information
Drug ID	D05EKM
Former ID	DIB002600
Drug Name	FR-121196
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[544870]
Company	Fujisawa Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C12H16FN3O3S
Canonical SMILES	S(=O)(=O)(NN1CCN(C(=O)C)CC1)c1ccc(cc1)F
CAS Number	CAS 133920-65-7
PubChem Compound ID	131688
Target and Pathway
Target(s)	Somatostatin receptor type 4	Target Info	Modulator	[533791]
	Somatostatin receptor type 2	Target Info	Modulator	[533791]
	Somatostatin receptor type 3	Target Info	Modulator	[530618], [532210]
	Somatostatin receptor type 5	Target Info	Modulator	[533791]
	Somatostatin receptor 1	Target Info	Modulator	[530618], [532210]
KEGG Pathway	Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretionhsa04080:Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
PathWhiz Pathway	Gastric Acid Production
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
References
Ref 544870	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001380)
Ref 530618	Mol Endocrinol. 2010 Feb;24(2):436-46. Epub 2010 Jan 5.Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation.
Ref 532210	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 533791	Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34.

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