Drug Information

Drug General Information
Drug ID
D05GNW
Former ID
DIB005823
Drug Name
AZD-9164
Synonyms
IDDBCP239717
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Phase 2 [522724]
Company
AstraZeneca plc
Structure
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2D MOL

3D MOL
Canonical SMILES
C1[N@+]2(C[C@@H]([C@@H](C1)CC2)Oc1ccc(c(c1)F)C)Cc1cc(no<br />1)C(O)(c1ccccc1)c1ccccc1.[Br-]
Target and Pathway
Target(s) Muscarinic receptor Target Info Antagonist [531685]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 522724ClinicalTrials.gov (NCT00939211) The Study Will Evaluate the Effect of AZD9164 in Patients With Chronic Obstructive Pulmonary Disease. U.S. National Institutes of Health.
Ref 531685The discovery of AZD9164, a novel muscarinic M3 antagonist. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7440-6.

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