Drug General Information
Drug ID
D02VHE
Former ID
DIB005923
Drug Name
A-72055
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [545007]
Company
Abbott Laboratories
Structure
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2D MOL

3D MOL

Canonical SMILES
N1(C(OC2(C1)CCN(CC2)C)C)C=O
CAS Number
CAS 150358-76-2
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator [550836]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 545007Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001856)
Ref 550836US patent application no. 2011,0020,423, Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation.

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