Drug Information
Drug General Information | |||||
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Drug ID |
D0A3HB
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Former ID |
DAP000662
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Drug Name |
Propofol
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Synonyms |
Ampofol; Aquafol; Diisopropylphenol; Dipravan; Diprivan; Disoprivan; Disoprofol; Fresofol; Ivofol; PFL; Propofolum; Rapinovet; Recofol; Abbott Brand of Propofol; Alpha Brand of Propofol; Astra Brand of Propofol; AstraZeneca Brand of Propofol; Braun Brand of Propofol; Curamed Brand of Propofol; Diprivan Injectable emulsion; Fresenius Brand of Propofol; Fresenius Kabi Brand of Propofol; Juste Brand of Propofol; Parnell Brand of Propofol; Pisa Brand of Propofol; Propofol Abbott; Propofol Fresenius; Propofol MCT; Propofol Rovi; Propofolum [Latin]; Rovi Brand of Propofol; Schering Brand of Propofol; Zeneca Brand of Propofol; AM-149; DDS-04F; Diprivan (TN); Propofol IDD-D; Propofol-Lipuro; ZD-0859; Ghl.PD_Mitscher_leg0.558; Propofol [USAN:INN:BAN]; Propofol (JAN/USAN/INN); Propofol(2,6-Diisopropylphenol); 2, 6-Diisopropylphenol; 2,6 Diisopropylphenol; 2,6-Bis(1-methylethyl)phenol; 2,6-Bis(Isopropyl)-phenol; 2,6-DIISOPROPYLPHENOL; 2,6-Diisopropyl phenol; 2,6-Diisopropylphenol; 2,6-bis(1-methylethyl)-phenol; 2,6-di(propan-2-yl)phenol
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Drug Type |
Small molecular drug
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Therapeutic Class |
Hypnotics and Sedatives
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Company |
AstraZeneca
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Structure |
Download2D MOL |
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Formula |
C12H18O
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InChI |
InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
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InChIKey |
OLBCVFGFOZPWHH-UHFFFAOYSA-N
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CAS Number |
CAS 2078-54-8
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PubChem Compound ID | |||||
PubChem Substance ID |
9726, 71265, 219945, 838001, 3132933, 5371511, 7847615, 7889810, 7980416, 7984535, 8001758, 8153049, 10513227, 11111121, 11111122, 11466959, 11468079, 11486767, 12012653, 12055958, 14772701, 17389856, 17405000, 24278001, 24902022, 26612728, 26697200, 26747380, 26753044, 26753045, 26753046, 29224021, 29334775, 29833842, 46504991, 47193694, 47216867, 47216868, 47216869, 47365303, 47662396, 47662397, 47662398, 48416482, 48424532, 49699215, 49855158, 50105615, 51074363, 53777543
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ChEBI ID |
ChEBI:44915
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SuperDrug ATC ID |
N01AX10
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SuperDrug CAS ID |
cas=002078548
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Target and Pathway | |||||
Target(s) | Fatty-acid amide hydrolase | Target Info | Inhibitor | [535758], [536166] | |
BioCyc Pathway | Anandamide degradation | ||||
KEGG Pathway | Retrograde endocannabinoid signaling | ||||
PANTHER Pathway | Anandamide degradation | ||||
References | |||||
Ref 525679 | Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000 Feb;7(2):249-71. | ||||
Ref 535758 | The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13. | ||||
Ref 536166 | Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. | ||||
Ref 540866 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5464). |
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