Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R1QE
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| Former ID |
DAP000780
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| Drug Name |
Ibuprofen
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| Synonyms |
Actiprofen; Adran; Advil; Alaxan; Algofen; Amelior; Amersol; Amibufen; Anafen; Anco; Andran; Anflagen; Antagil; Antalfene; Antarene; Antiflam; Apsifen; Artofen; Artril; Balkaprofen; Betaprofen; Bloom; Bluton; Brofen; Brufanic; Brufen; Bruflam; Brufort; Buburone; Bufeno; Bufigen; Bukrefen; Bupron; Buracaps; Burana; Butylenin; Carol;Cesra; Citalgan; Cobo; Codral; Combiflam; Cunil; Daiprophen; Dalsy; Dansida; Dentigoa; Dibufen; Dignoflex; Dolgirid; Dolgit; Dolibu; Dolmaral; Dolocyl; Dolofen; Dolofin; Dolofort; Dologel; Dolomax; Doloren; Dolormin; Doltibil; Dolven; Dorival; Drin; Duafen; Duobrus; Dysdolen; Easifon; Ebufac; Emflam; Epobron; Eputex; Ergix; Esprenit; Exneural; Faspic; Femadon; Femafen; Femapirin; Femidol; Fenbid;Fendol; Fenspan; Fibraflex; Gelufene; Gofen; Grefen; Gynofug; Haltran; Ibol; Ibren; Ibu; Ibubest; Ibubeta; Ibucasen; Ibudol; Ibudolor; Ibufen; Ibuflamar; Ibufug; Ibugel; Ibugen; Ibugesic; Ibuhexal; Ibulagic; Ibular; Ibulav; Ibuleve; Ibulgan; Ibumed; Ibumerck; Ibumetin; Ibupirac; Ibuprin; Ibuprocin; Ibuprofene; Ibuprofeno; Ibuprofenum; Ibuprohm; Ibuprophen; Ibusal; Ibutid; Ifen; Inabrin; Inflam; Inoven; Ipren; Irfen; Isodol; Jenaprofen; Junifen; Kesan; Kratalgin; Lamidon; Lebrufen; Librofem; Lidifen; Liptan; Lopane; Malafene; Manypren; Medipren; Melfen; Mensoton; Midol; Moment; Motrin; Mynosedin; Napacetin; Narfen; Neobrufen; Nerofen; Noalgil; Nobafon; Nobfelon; Nobfen; Nobgen; Noritis; Norton; Novadol; Novogent; Novoprofen; Nuprilan; Nuprin; Nurofen; Optifen; Opturem; Oralfene; Ostarin; Ostofen; Ozonol; Paduden; Panafen; Pantrop; Paxofen; PediaProfen; Perofen; Proartinal; Profen; Proflex; Provon; Quadrax; Rafen; Ranofen; Rebugen; Relcofen; Rhinadvil; Rofen; Roidenin; Rufen; Rufin; Rupan; Sadefen; Salivia; Salprofen; Seclodin; Sednafen; Seklodin; Seskafen; Siyafen; Solpaflex; Solufen; Stelar; Sugafen; Suprafen; Suspren; Syntofene; Tabalon; Tatanal; Tempil; Tofen; Tonal; Trendar; Unipron; Upfen; Uprofen; Urem; Zafen; Zofen; DOLO PUREN; Deep Relief; Donjust B; Motrin IB; Novogent N; Togal N; Adex 200; Artril 300; Brufen 400; I 4883; IP 82; IP82; Midol 200; RD 13621; Tabalon 400; U 18573; UCB 79171; VUFB 9649; Act-3; Advil (TN); Ak+C2278tren; Aktre (TN); Alaxan (TN); Algoflex (TN); Alivium (TN); Am-Fam 400; Apsifen-F; Arthrofen (TN); Bonifen (TN); Brufen (TN); Bugesic (TN); Burana (TN); Caldolor (TN); Calprofen (TN); Cap-Profen; Dalsy (TN); Dismenol (TN); Diverin (TN); Dolgit (TN); Dolo-Dolgit; Dolofen-F; Dolofort (TN); Doloraz (TN); Dolormin (TN); Dorival (TN); Dura-Ibu; Ebufac (TN); Emflam-200; EmuProfen (TN); Espidifen (TN); Eve (TN); Fenbid (TN); Fenpaed (TN); Finalflex (TN); Galprofen (TN); Hedex (TN); Herron Blue (TN); IB-100; IBUFEN (TN); IP-82; Ibalgin (TN); Ibu-Attritin; Ibu-Tab; Ibu-Tab 200; Ibu-slo; Ibu-slow; IbuHEXAL (TN); Ibugel (TN); Ibuleve (TN); Ibum (TN); Ibumax (TN); Ibumetin (TN); Ibuprom (TN); Ibuprosyn (TN); Ibux (TN); Ibuxin (TN); Ipren (TN); Kratalgin (TN); Medicol (TN); Moment (TN); Motrin (TN); Nagifen-D; Narfen (TN); Neo-Helvagit; Neo-Mindol; Neobrufen (TN); Neofen (TN); Norvectan (TN); Novo-Profen; Nuprin (TN); Nureflex (TN); Nurofen (TN); Orbifen (TN); Panafen (TN); Pedia-Profen; Perifar (TN); Profin (TN); Ratiodolor (TN); Retard (TN); Rimafen (TN); Salvarina (TN); Solpaflex (TN); Spedifen (TN); Speedpain NANO (TN); Spidifen (TN); Tab-Profen; U-18573; Upfen (TN); ACHES-N-PAIN; Act-3 (TN); Dolo-Spedifen (TN); I-profen (TN); IBU-Ratiopharm (TN); Ibu-Vivimed (TN); R.D. 13621; U-18,573
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Analgesics
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| Structure |
|
Download2D MOL |
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| Formula |
C13H18O2
|
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| InChI |
InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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| InChIKey |
HEFNNWSXXWATRW-UHFFFAOYSA-N
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| CAS Number |
CAS 15687-27-1
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4743, 138460, 611158, 855602, 3140375, 7647311, 7847194, 7979568, 8062120, 8147017, 8149384, 8152318, 10509306, 11152950, 11336062, 11361301, 11363743, 11366305, 11368867, 11371490, 11373528, 11377029, 11406458, 11462273, 11483914, 11487945, 11490281, 11491830, 11494663, 14822381, 17405252, 24277715, 24896130, 25623341, 26611780, 26679534, 26747223, 26747224, 26752326, 26758921, 29222795, 46507255, 47217047, 47515579, 47885643, 47959999, 48413891, 48416098, 49761821, 49831178
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| ChEBI ID |
ChEBI:5855
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| SuperDrug ATC ID |
C01EB16; G02CC01; M01AE01; M02AA13
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| SuperDrug CAS ID |
cas=015687271
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| Target and Pathway | |||||
| Target(s) | Prostaglandin G/H synthase 2 | Target Info | Inhibitor | [535585], [537246], [538149] | |
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| NF-kappa B signaling pathway | |||||
| VEGF signaling pathway | |||||
| TNF signaling pathway | |||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Oxytocin signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Leishmaniasis | |||||
| Pathways in cancer | |||||
| Chemical carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| Small cell lung cancer | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| References | |||||
| Ref 536772 | New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. | ||||
| Ref 539773 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2713). | ||||
| Ref 535585 | The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. J Cancer Res Clin Oncol. 2002 Oct;128(10):525-32. Epub 2002 Aug 29. | ||||
| Ref 537246 | Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44. Epub 2009 Apr 18. | ||||
| Ref 538149 | Analysis of prostaglandin G/H synthase-2 inhibition using peroxidase-induced luminol luminescence. Anal Biochem. 1998 Nov 15;264(2):216-21. | ||||
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