Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0QK5X
|
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| Former ID |
DNAP001680
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| Drug Name |
Enzalutamide
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| Synonyms |
MDV3100; Enzalutamide (AR inhibitor)
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| Drug Type |
Small molecular drug
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| Company |
Astellas Pharma
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H16F4N4O2S
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| InChI |
InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)
|
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| InChIKey |
WXCXUHSOUPDCQV-UHFFFAOYSA-N
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| CAS Number |
CAS 915087-33-1
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| PubChem Compound ID | |||||
| PubChem Substance ID |
22422973, 26557832, 33334455, 85286065, 99437051, 103756429, 124757115, 125163919, 125299336, 125749051, 126731384, 131480739, 135261179, 135684120, 135727393, 136367372, 136367882, 136375508, 137009352, 137275964, 143499468, 144116190, 151990441, 152237529, 152258872, 152344309, 160645896, 160647721, 160821662, 162011754, 162036208, 162196987, 163091639, 163312249, 164041953, 164154607, 164193917, 164761729, 165245624, 172093747, 172914062, 174477518, 174531457, 175267791, 175427141, 177748753, 178103418, 185989448, 188899565, 198993053
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| ChEBI ID |
ChEBI:68534
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| SuperDrug ATC ID |
L02BB03
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | Androgen receptor | Target Info | Modulator | [551871] | |
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Coregulation of Androgen receptor activity | |||||
| Regulation of Androgen receptor activity | |||||
| Nongenotropic Androgen signaling | |||||
| Regulation of nuclear beta catenin signaling and target gene transcription | |||||
| FOXA1 transcription factor network | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
| Ref 524719 | ClinicalTrials.gov (NCT02116582) A Study to Evaluate Enzalutamide After Abiraterone in Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health. | ||||
| Ref 541894 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6812). | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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